Being a BCS class II drug and a good substrate for microsomal enzymes, tamoxifen (TAM)
offers a scope for research owing to poor aqueous solubility and compromised …

Chitosan is a widely employed polysaccharide with positive zeta-potential and better
tissue/cell adhesion. Its hydrophilicity, high viscosity, and insolubility at physiological pH are …

The present work aims to develop tamoxifen-loaded polymeric micelles and explore their
potential in topical delivery of the drug to breast cancer cells. The PLGA–PEG copolymer …

Tamoxifen (TAM) is frequently prescribed for the management breast cancer, but is
associated with the challenges like compromised aqueous solubility and poor bioavailability …

Breast cancer is believed as the second most common cause of cancer-related deaths in
women for which tamoxifen is frequently prescribed. Despite many promises, tamoxifen is …

Chemical modification of chitosan derivatives with hydrophobic fatty acids to enhance their
self-aggregation behavior is well established. Previously our group reported low molecular …

The objective of the current work was to develop chitosan based lipid nanocarriers for the
oral controlled release of tamoxifen citrate (TC). The ionic gelation method was used to …

Poor aqueous solubility is one of the key reasons for slow dissolution rate and poor
intestinal absorption and finally that causes low therapeutic efficacy of many existing drugs …

This study was undertaken to develop and investigate the effect of tamoxifen polymer-lipid
hybrid nanoparticles (Tmx-PLN) on its oral bioavailability and efficacy in the 7, 12 …

In this study, tamoxifen citrate-loaded chitosan nanoparticles (tamoxcL-ChtNPs) and
tamoxifen citrate-free chitosan nanoparticles (tamoxcF-ChtNPs) were prepared by an ionic …