Cell cycle progression in mammalian cells from G1 into S phase requires sensing and
integration of multiple inputs, in order to determine whether to continue to cellular DNA …

E2F transcription factors are thought to influence the G1–S cell-cycle transition by controlling
expression of genes required for growth and DNA synthesis. But emerging evidence …

Various studies now point to the role of cooperative transcription factor interactions as a
mechanism to achieve the necessary specificity in promoter recognition. An example can be …

Activation of E2F transcription factors is thought to drive the expression of genes essential
for the transition of cells from G1 to S phase and for the initiation of DNA replication …

Previous work has demonstrated the important role of E2F transcription activity in the
induction of S phase during the transition from quiescence to proliferation. In addition to the …

E2F transcription factors are known to be important for timely activation of G 1/S and G 2/M
genes required for cell cycle progression, but transcriptional mechanisms for deactivation of …

Although a number of transfection experiments have suggested potential targets for the
action of the E2F1 transcription factor, as is the case for many transcriptional regulatory …

Transcription factor LSF is required for progression from quiescence through the cell cycle,
regulating thymidylate synthase (Tyms) expression at the G1/S boundary. Given the constant …

The transcription factor E2F plays an important role in G 1 to S phase transition in the higher
eukaryotic cell cycle. Although a number of E2F-inducible genes have been identified, the …

The E2F transcription factors are essential for regulating the correct timing of activation of
several genes whose products are implicated in cell proliferation and DNA replication. The …