Cyclin A-kinase, an enzyme required for coordinating S phase progression, forms stable in
vivo complexes with E2F-1, a growth-promoting transcription factor, which binds to the …

Maintaining quiescent cells in G0 phase is achieved in part through the multiprotein subunit
complex known as DREAM, and in human cell lines the transcription factor E2F4 directs this …

A considerable body of evidence points to a role for both cyclin E/cyclin-dependent kinase
(cdk) 2 activity and E2F transcription activity in the induction of S phase. We show that …

The Rb/E2F complex represses S‐phase genes both in cycling cells and in cells that have
permanently exited from the cell cycle and entered a terminal differentiation pathway. Here …

Cell cycle proteins are important regulators of diverse cell fate decisions, and in this capacity
have pivotal roles in neurogenesis and brain development. The mechanisms by which cell …

E2F-1, a member of the E2F transcription factor family, contributes to the regulation of the G1-
to-S phase transition in higher eukaryotic cells. E2F-1 forms a heterodimer with DP-1 and …

Previous work has provided evidence for E2F‐dependent transcription control of both G1/S‐
and G2/M‐regulated genes. Analysis of the G2‐regulated cdc2 and cyclin B1 genes reveals …

Because of its expression in numerous cells, the herpes simplex virus thymidine kinase
promoter (HSV-TK) is one of the best characterized promoters. Using the HSV-TK promoter …

The E2F family of transcription factors are essential for the regulation of genes required for
appropriate progression through the cell cycle. Five members of the E2F family have been …

The E2f3 locus encodes two Rb-binding gene products, E2F3a and E2F3b, which are
differentially regulated during the cell cycle and are thought to be critical for cell cycle …