Triple therapy in the management of chronic obstructive pulmonary disease: systematic review and meta-analysis

Y Zheng, J Zhu, Y Liu, W Lai, C Lin, K Qiu, J Wu, W Yao - Bmj, 2018 - bmj.com
Objective To compare the rate of moderate to severe exacerbations between triple therapy
and dual therapy or monotherapy in patients with chronic obstructive pulmonary disease …

Single-inhaler triple therapy in patients with chronic obstructive pulmonary disease: a systematic review

S Langham, J Lewis, N Pooley, N Embleton… - Respiratory …, 2019 - Springer
Background Guidelines recommend that treatment with a long-acting β 2 agonist (LABA), a
long-acting muscarinic antagonist (LAMA), and inhaled corticosteroids (ICS), ie triple …

The effects of single inhaler triple therapy vs single inhaler dual therapy or separate triple therapy for the management of chronic obstructive pulmonary disease: a …

CC Lai, CH Chen, CYH Lin, CY Wang… - International journal of …, 2019 - Taylor & Francis
Background This study aims to compare the effects of single inhaler triple therapy comprised
of inhaled corticosteroids (ICSs), long-acting β2-agonists (LABAs), and long-acting …

Clinical concepts for triple therapy use in patients with COPD: a Delphi consensus

M Miravitlles, S Acharya, B Aggarwal… - … Journal of Chronic …, 2023 - Taylor & Francis
Purpose Role of triple therapy in chronic obstructive pulmonary disease (COPD)
management is supported by growing evidence, but consensus is lacking on various …

FULFIL trial: once-daily triple therapy for patients with chronic obstructive pulmonary disease

DA Lipson, H Barnacle, R Birk, N Brealey… - American journal of …, 2017 - atsjournals.org
Rationale: Randomized data comparing triple therapy with dual inhaled corticosteroid
(ICS)/long-acting β2-agonist (LABA) therapy in patients with chronic obstructive pulmonary …

Triple therapy versus single and dual long-acting bronchodilator therapy in COPD: a systematic review and meta-analysis

M Cazzola, P Rogliani, L Calzetta… - European Respiratory …, 2018 - Eur Respiratory Soc
We performed a meta-analysis to compare the impact of triple combination therapy with
inhaled corticosteroids (ICS), long-acting β2-agonists (LABAs) and long-acting muscarinic …

Triple therapy (ICS/LABA/LAMA) in COPD: time for a reappraisal

L Vanfleteren, LM Fabbri, A Papi… - … journal of chronic …, 2018 - Taylor & Francis
Recently, two “fixed triple” single-inhaler combinations of an inhaled corticosteroid (ICS), a
long-acting β2-agonist (LABA), and a long-acting muscarinic antagonist (LAMA) have …

Triple therapy versus dual or monotherapy with long-acting bronchodilators for chronic obstructive pulmonary disease. A systematic review and meta-analysis

MJ Mammen, DR Lloyd, S Kumar… - Annals of the …, 2020 - atsjournals.org
Rationale: There is uncertainty on the use of using triple therapy (inhaled
corticosteroids/long-acting β-agonist/long-acting muscarinic antagonist) inhaler therapy for …

Triple therapy in COPD: what we know and what we don't

PMA Calverley, H Magnussen… - COPD: Journal of …, 2017 - Taylor & Francis
Triple inhaled therapy for chronic obstructive pulmonary disease (COPD) consists of an
inhaled corticosteroid (ICS), a long-acting β2-agonist (LABA) and a long-acting muscarinic …

Triple inhaler versus dual bronchodilator therapy in COPD: real-world effectiveness on mortality

S Suissa, S Dell'Aniello, P Ernst - COPD: Journal of Chronic …, 2022 - Taylor & Francis
Randomized trials of triple therapy including an inhaled corticosteroid (ICS) for chronic
obstructive pulmonary disease (COPD) reported remarkable benefits on mortality compared …