Complex diseases are characterized by spatiotemporal cellular and molecular changes that
may be difficult to comprehensively capture. However, understanding the spatiotemporal …

Recent single-cell technologies have enabled researchers to simultaneously assess the
transcriptomes and other modalities of thousands of cells within their spatial context. Here …

Microglia and central nervous system (CNS)-associated macrophages (CAMs), such as
perivascular and meningeal macrophages, are implicated in virtually all diseases of the …

Our understanding of astrocytes and their role in neurological diseases has increased
considerably over the past two decades as the diverse roles of these cells have become …

Abstract Astrocytes make up 20–40% of glial cells within the central nervous system (CNS)
and provide several crucial functions, ranging from metabolic and structural support to …

Astrocytes are the predominant glial type in the central nervous system and play important
roles in assisting neuronal function and network activity. Astrocytes exhibit complex …

Microglia are specialized macrophages in the brain parenchyma that exist in multiple
transcriptional states and reside within a wide range of neuronal environments,,–. However …

Microglia are the resident immune cells of the central nervous system (CNS) that have
distinct ontogeny from other tissue macrophages and play a pivotal role in health and …

The precise spatial localization of molecular signals within tissues richly informs the
mechanisms of tissue formation and function. Previously, we developed Slide-seq, a …

Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we
lack a comprehensive understanding of the signaling pathways that regulate this process …