The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid
A Bizhanova, P Kopp - Endocrinology, 2009 - academic.oup.com
Thyroid hormones are essential for normal development and metabolism. Thyroid hormone
biosynthesis requires iodide uptake into the thyrocytes and efflux into the follicular lumen …
biosynthesis requires iodide uptake into the thyrocytes and efflux into the follicular lumen …
Pendred syndrome and iodide transport in the thyroid
P Kopp, L Pesce, JC Solis-S - Trends in Endocrinology & Metabolism, 2008 - cell.com
Pendred syndrome is an autosomal recessive disorder characterized by sensorineural
hearing impairment, presence of goiter, and a partial defect in iodide organification, which …
hearing impairment, presence of goiter, and a partial defect in iodide organification, which …
Mutations of the PDS Gene, Encoding Pendrin, Are Associated with Protein Mislocalization and Loss of Iodide Efflux: Implications for Thyroid Dysfunction in Pendred …
JP Taylor, RA Metcalfe, PF Watson… - The Journal of …, 2002 - academic.oup.com
Pendred syndrome (PDS) is an autosomal recessive disorder characterized by deafness
and goiter. Phenotypic heterogeneity is observed in affected individuals, and thyroid …
and goiter. Phenotypic heterogeneity is observed in affected individuals, and thyroid …
Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells
A Yoshida, S Taniguchi, I Hisatome… - The Journal of …, 2002 - academic.oup.com
The Pendred syndrome gene encodes a 780-amino acid putative transmembrane protein
(pendrin) that is expressed in the apical membrane of thyroid follicular cells. Although …
(pendrin) that is expressed in the apical membrane of thyroid follicular cells. Although …
TSH regulates pendrin membrane abundance and enhances iodide efflux in thyroid cells
L Pesce, A Bizhanova, JC Caraballo… - …, 2012 - academic.oup.com
Thyroid hormones are essential for normal development and metabolism. Their synthesis
requires transport of iodide into thyroid follicles. The mechanisms involving the apical efflux …
requires transport of iodide into thyroid follicles. The mechanisms involving the apical efflux …
Genetics and phenomics of Pendred syndrome
A Bizhanova, P Kopp - Molecular and cellular endocrinology, 2010 - Elsevier
Pendred syndrome is an autosomal recessive disorder characterized by sensorineural
deafness, goiter and a partial defect in iodide organification. Goiter development and …
deafness, goiter and a partial defect in iodide organification. Goiter development and …
Functional characterization of pendrin in a polarized cell system: evidence for pendrin-mediated apical iodide efflux
MP Gillam, AR Sidhaye, EJ Lee, J Rutishauser… - Journal of Biological …, 2004 - ASBMB
Pendred's syndrome is an autosomal recessive disorder characterized by sensorineural
deafness, goiter, and impaired iodide organification. It is caused by mutations in the …
deafness, goiter, and impaired iodide organification. It is caused by mutations in the …
Pendrin, the Protein Encoded by the Pendred Syndrome Gene (PDS), Is an Apical Porter of Iodide in the Thyroid and Is Regulated by Thyroglobulin in FRTL-5 Cells
IE Royaux, K Suzuki, A Mori, R Katoh, LA Everett… - …, 2000 - academic.oup.com
Pendred syndrome is an autosomal recessive disorder characterized by congenital
deafness and thyroid goiter. The thyroid disease typically develops around puberty and is …
deafness and thyroid goiter. The thyroid disease typically develops around puberty and is …
Sodium iodide symporter and pendrin expression in human thyroid tissues
C Mian, L Lacroix, L Alzieu, M Nocera, M Talbot… - Thyroid, 2001 - liebertpub.com
Thyroid cells synthesize thyroid hormones through a multistep process during which iodide
is transported through the basolateral and the apical membranes of thyrocytes. Two genes …
is transported through the basolateral and the apical membranes of thyrocytes. Two genes …
Pendred syndrome
JL Wémeau, P Kopp - Best Practice & Research Clinical Endocrinology & …, 2017 - Elsevier
Pendred syndrome is an autosomal recessive disorder that is classically defined by the
combination of sensorineural deafness/hearing impairment, goiter, and an abnormal …
combination of sensorineural deafness/hearing impairment, goiter, and an abnormal …