Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLpro: Insights from the Computational and Experimental Investigations
N Khamto, K Utama, P Boontawee… - Journal of Chemical …, 2024 - ACS Publications
The emergence of the COVID-19 situation has become a global issue due to the lack of
effective antiviral drugs for treatment. Flavonoids are a class of plant secondary metabolites …
effective antiviral drugs for treatment. Flavonoids are a class of plant secondary metabolites …
[HTML][HTML] Potential bioactive glycosylated flavonoids as SARS-CoV-2 main protease inhibitors: A molecular docking and simulation studies
SA Cherrak, H Merzouk, N Mokhtari-Soulimane - Plos one, 2020 - journals.plos.org
A novel coronavirus responsible of acute respiratory infection closely related to SARS-CoV
has recently emerged. So far there is no consensus for drug treatment to stop the spread of …
has recently emerged. So far there is no consensus for drug treatment to stop the spread of …
[HTML][HTML] In silico evaluation of different flavonoids from medicinal plants for their potency against SARS-CoV-2
The ongoing pandemic situation of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) poses a global threat to both the world economy and public …
coronavirus 2 (SARS-CoV-2) poses a global threat to both the world economy and public …
Rational design of flavonoid based potential inhibitors targeting SARS-CoV 3CL protease for the treatment of COVID-19
The current outbreak of Coronavirus Disease 2019 (COVID-19) pandemic has reported
thousands of deaths worldwide due to the rapid transmission rate and the lack of antiviral …
thousands of deaths worldwide due to the rapid transmission rate and the lack of antiviral …
[PDF][PDF] Molecular docking simulation studies, toxicity study, bioactivity prediction, and structure-activity relationship reveals rutin as a potential inhibitor of SARS-CoV-2 …
JH Zothantluanga - J. Sci. Res, 2021 - researchgate.net
Coronavirus disease 2019 (COVID-19) pandemic has infected billions and has killed
millions of people. Despite the advancement in drugs and vaccines, the COVID-19 …
millions of people. Despite the advancement in drugs and vaccines, the COVID-19 …
Evaluation of apigenin-based biflavonoid derivatives as potential therapeutic agents against viral protease (3CLpro) of SARS-CoV-2 via molecular docking, molecular …
R Abdizadeh, F Hadizadeh… - Journal of Biomolecular …, 2023 - Taylor & Francis
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative
agent of the pandemic COVID-19 disease that affects human respiratory function. Despite …
agent of the pandemic COVID-19 disease that affects human respiratory function. Despite …
Rutin and flavone analogs as prospective SARS-CoV-2 main protease inhibitors: In silico drug discovery study
MAA Ibrahim, EAR Mohamed… - Journal of Molecular …, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is a new pandemic characterized by quick
spreading and illness of the respiratory system. To date, there is no specific therapy for …
spreading and illness of the respiratory system. To date, there is no specific therapy for …
Evaluation of flavonoids as potential inhibitors of the SARS-CoV-2 main protease and spike RBD: Molecular docking, ADMET evaluation and molecular dynamics …
H Hadni, A Fitri, AT Benjelloun, M Benzakour… - Journal of the Indian …, 2022 - Elsevier
The 3CLpro main protease and the RDB spike (s) protein of SARS-CoV-2 are critical targets
in the treatment of coronavirus 19 disease (COVID-19), as they are responsible for the …
in the treatment of coronavirus 19 disease (COVID-19), as they are responsible for the …
Comprehensive in silico screening of flavonoids against SARS-CoV-2 main protease
MS Moezzi - Journal of Biomolecular Structure and Dynamics, 2023 - Taylor & Francis
In the current pandemic caused by the new coronavirus (SARS-CoV-2), computational drug
discovery can play an essential role in finding potential therapeutic agents. Thanks to its anti …
discovery can play an essential role in finding potential therapeutic agents. Thanks to its anti …
Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (Mpro) inhibitors to unveil a hope against COVID-19
Abstract SARS-CoV-2, a rapidly spreading new strain of human coronavirus, has affected
almost all the countries around the world. The lack of specific drugs against SARS-CoV-2 is …
almost all the countries around the world. The lack of specific drugs against SARS-CoV-2 is …