[HTML][HTML] The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis
M Roederer, L Quaye, M Mangino, MH Beddall… - Cell, 2015 - cell.com
Despite recent discoveries of genetic variants associated with autoimmunity and infection,
genetic control of the human immune system during homeostasis is poorly understood. We …
genetic control of the human immune system during homeostasis is poorly understood. We …
[HTML][HTML] Unraveling the genetics of autoimmunity
LA Zenewicz, C Abraham, RA Flavell, JH Cho - Cell, 2010 - cell.com
The chronic autoimmune diseases include multiple complex genetic disorders. Recently,
genome-wide association studies (GWAS) have identified a large number of major loci, with …
genome-wide association studies (GWAS) have identified a large number of major loci, with …
Common genetic factors among autoimmune diseases
Autoimmune diseases display a high degree of comorbidity within individuals and families,
suggesting shared risk factors. Over the past 15 years, genome-wide association studies …
suggesting shared risk factors. Over the past 15 years, genome-wide association studies …
Autoimmune diseases—connecting risk alleles with molecular traits of the immune system
M Gutierrez-Arcelus, SS Rich… - Nature Reviews …, 2016 - nature.com
Genome-wide strategies have driven the discovery of more than 300 susceptibility loci for
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …
Genetic basis of autoimmunity
Autoimmune diseases affect up to approximately 10% of the population. While rare
Mendelian autoimmunity syndromes can result from monogenic mutations disrupting …
Mendelian autoimmunity syndromes can result from monogenic mutations disrupting …
Immune-mediated disease genetics: the shared basis of pathogenesis
C Cotsapas, DA Hafler - Trends in immunology, 2013 - cell.com
Recent genetic studies in multiple autoimmune and inflammatory diseases have identified
hundreds of genomic loci harboring risk variants. These variants are shared between …
hundreds of genomic loci harboring risk variants. These variants are shared between …
Approaches and advances in the genetic causes of autoimmune disease and their implications
JRJ Inshaw, AJ Cutler, OS Burren, MI Stefana… - Nature …, 2018 - nature.com
Genome-wide association studies are transformative in revealing the polygenetic basis of
common diseases, with autoimmune diseases leading the charge. Although the field is just …
common diseases, with autoimmune diseases leading the charge. Although the field is just …
Genetics of autoimmune diseases—disorders of immune homeostasis
PK Gregersen, TW Behrens - Nature Reviews Genetics, 2006 - nature.com
In the past few years, our extensive knowledge of the mammalian immune system and our
increasing ability to understand the genetic causes of complex human disease have opened …
increasing ability to understand the genetic causes of complex human disease have opened …
The immunogenetic architecture of autoimmune disease
A Goris, A Liston - Cold Spring Harbor perspectives in …, 2012 - cshperspectives.cshlp.org
The development of most autoimmune diseases includes a strong heritable component. This
genetic contribution to disease ranges from simple Mendelian inheritance of causative …
genetic contribution to disease ranges from simple Mendelian inheritance of causative …
[HTML][HTML] Genetic variants regulating immune cell levels in health and disease
The complex network of specialized cells and molecules in the immune system has evolved
to defend against pathogens, but inadvertent immune system attacks on" self" result in …
to defend against pathogens, but inadvertent immune system attacks on" self" result in …