We report on the influence of~ 22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …

Although genome-wide association studies have implicated many individual loci in complex
diseases, identifying the exact causal alleles and the cell types within which they act …

Recent genetic studies have revealed shared immunological mechanisms in several
immune-related disorders that further our understanding of the development and …

Genome-wide association studies (GWASs) have uncovered hundreds of autoimmune
disease-associated loci; however, the causal genetic variants within each locus are mostly …

Genetic studies have revealed many variant loci that are associated with immune-mediated
diseases. To elucidate the disease pathogenesis, it is essential to understand the function of …

Effective immunity requires a complex network of cellular and humoral components that
interact with each other and are influenced by different environmental and host factors. We …

Genome-wide association studies (GWASs) for autoimmune diseases (ADs) have identified
many risk loci and have provided insights into the etiology of each disease. Some of these …

Most of the recently identified autoimmunity loci are shared among multiple autoimmune
diseases. The pattern of genetic association with autoimmune phenotypes varies …

Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …

Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high …