Autoimmune diseases are known to have a multifactorial pathogenesis, with both
environmental and inherited components. Wide technical progresses together with the …

Given the many cell types and molecular components of the human immune system, along
with vast variations across individuals, how should we go about developing causal and …

The quantification and characterization of circulating immune cells provide key indicators of
human health and disease. To identify the relative effects of environmental and genetic …

The diversity and activity of leukocytes is controlled by genetic and environmental influences
to maintain balanced immune responses. However, the relative contribution of …

Autoimmune diseases occur when an individual's own immune system attacks and destroys
his or her healthy cells and tissues. Although it is clear that environmental stimuli can …

Genome-wide association (GWA) studies have identified numerous, replicable, genetic
associations between common single nucleotide polymorphisms (SNPs) and risk of …

Genome-wide association studies (GWAS) have mapped thousands of susceptibility loci
associated with immune-mediated diseases. To assess the extent of the genetic sharing …

The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …

Background Humoral immune responses to infectious agents or vaccination vary
substantially among individuals, and many of the factors responsible for this variability …

Genome-wide association studies (GWASs) have been widely applied to identify genetic
factors that affect complex diseases or traits. Presently, the GWAS Catalog includes> 2800 …