Mast cells are widely recognized as effector cells of allergic inflammatory reactions. They
contribute to the pathogenesis of different chronic inflammatory diseases, wound healing …

Mast cells are responsible for the majority of allergic conditions. It was originally thought that
almost all allergic events were mediated directly only via the high-affinity immunoglobulin E …

Mast cells play important roles in host defence against pathogens, as well as being a key
effector cell in diseases with an allergic basis such as asthma and an increasing list of other …

Mast cells (MCs) play a critical role in allergic inflammation. Although purinergic signalling is
implicated in the regulation of various immune responses, its role in MC function is not fully …

ATP and ADP activate functionally distinct G protein-coupled purinergic (P2Y) receptors. We
determined the expression and function of adenine nucleotide-specific P2Y receptors on …

Extracellular ATP released from stimulated and/or damaged cells modulates physiological
responses via stimulation of various purinoceptors. We previously showed that ATP …

Mast cell degranulation affects many conditions, eg, asthma and urticaria. We explored the
potential role of the P2Y 14 receptor (P2Y 14 R) and other P2Y subtypes in degranulation of …

Mast cells are key regulators in allergy and inflammation, and release histamine upon
clustering of their IgE receptors. Here we demonstrate that murine mast cell responses are …

Extracellular ATP activates inflammasome and triggers the release of multiple cytokines in
various immune cells, a process primarily mediated by P2X7 receptors. However, the …

Mast cells are known effector cells in allergic and inflammatory diseases, but their precise
roles in intestinal inflammation remain unknown. Here we show that activation of mast cells …