Overproduction of reactive oxygen species (ROS) or exhaustion of antioxidants may cause
oxidative stress which is a major factor of defective insulin secretion and increases …

Objective Insulin has well-known activities in controlling energy metabolism, cellular
proliferation and biosynthesis of functional molecules to maintain a biological homeostasis …

Chronic pancreatitis is characterized by progressive loss of exocrine and endocrine
functions of the pancreas and is considered to be the single most important cause for …

In type 2 diabetes, pancreatic β-cells cannot secret enough insulin compensate for insulin
resistance, which are often accompanied by abnormality in lipid metabolism such as …

Background: Increased levels of plasma cholesterol are a common feature of patient of type
2 diabetes. However, the links between elevated levels of low-density lipoprotein (LDL) and …

Pro‐inflammatory cytokines are implicated as the main mediators of β‐cell death during type
1 diabetes but the exact mechanisms remain unknown. This study examined the effects of …

Purpose: Obstructive sleep apnea hypopnea syndrome (OSAHS), a common sleep and
breathing disorder, is independently associated with metabolic dysfunction, including …

Background Reactive oxygen species (ROS) plays a vital role in the apoptosis of islet β-cells
in type 2 diabetes mellitus (T2DM). Sirt3 (Sirtuin 3, a deacetylase) and FoxO1 (a …

Several reducing sugars brought about apoptosis in isolated rat pancreatic islet cells and in
the pancreatic β-cell-derived cell line HIT. This apoptosis was characterized biochemically …

Sulfonylureas are considered to cause β-cell apoptosis. However, it is unclear how this
occurs and whether there is a difference in such effects among various sulfonylureas. Here …