Long-term ameliorative effects of the antidepressant fluoxetine exposure on cognitive deficits in 3× TgAD mice

L Jin, LF Gao, DS Sun, H Wu, Q Wang, D Ke, H Lei… - Molecular …, 2017 - Springer
Fluoxetine, a selective serotonin reuptake inhibitor, is neuroprotective; therefore, it has been
applied to treat some neurodegenerative disorders. For instance, chronic fluoxetine …

Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3ŨTgAD mice

DS Sun, LF Gao, L Jin, H Wu, Q Wang, Y Zhou, S Fan… - …, 2017 - Elsevier
Fluoxetine (FLX) has broad neurobiological functions and neuroprotective effects; however,
the preventive effects of FLX on cognitive impairments in Alzheimer's disease (AD) have not …

Fluoxetine delays the cognitive function decline and synaptic changes in a transgenic mouse model of early Alzheimer's disease

C Zhou, F Chao, Y Zhang, L Jiang… - Journal of …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
cognitive decline. Previous studies have reported that the syndrome of AD begins with …

Fluoxetine promotes hippocampal oligodendrocyte maturation and delays learning and memory decline in APP/PS1 mice

F Chao, Y Zhang, L Zhang, L Jiang, C Zhou… - Frontiers in Aging …, 2021 - frontiersin.org
Oligodendrogenesis dysfunction impairs memory consolidation in adult mice, and an
oligodendrocyte abnormality is an important change occurring in Alzheimer's disease (AD) …

Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression

HJ Jin, L Pei, YN Li, H Zheng, S Yang, Y Wan, L Mao… - Scientific reports, 2017 - nature.com
Fluoxetine, one of the selective serotonin reuptake inhibitor (SSRI) antidepressants, has
been thought to be effective for treating post-stroke depression (PSD). Recent work has …

Fluoxetine mitigates depressive-like behaviors in mice via anti-inflammation and enhancing neuroplasticity

X Qian, Z Zhong, Y Zhang, L Qiu, H Tan - Brain Research, 2024 - Elsevier
Neuroplasticity and inflammation represent a common final pathway for effective
antidepressant treatment. SSRIs are the most commonly prescribed medications for …

Fluoxetine reverses brain radiation and temozolomide-induced anxiety and spatial learning and memory defect in mice

H Gan, Q Zhang, B Zhu, S Wu… - Journal of …, 2019 - journals.physiology.org
Radiation therapy and concomitant temozolomide chemotherapy are commonly used in
treatment of brain tumors, but they may also result in behavioral impairments such as anxiety …

[HTML][HTML] Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's …

J Ma, Y Gao, L Jiang, F Chao, W Huang, C Zhou… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Selective serotonin reuptake inhibitors (SSRIs) have been reported to increase cognitive
performance in some clinical studies of Alzheimer's disease (AD). However, there is a lack of …

Fluoxetine protects against dendritic spine loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice

J Ma, Y Gao, W Tang, W Huang… - Current Alzheimer …, 2020 - ingentaconnect.com
Background: Studies have suggested that cognitive impairment in Alzheimer's disease (AD)
is associated with dendritic spine loss, especially in the hippocampus. Fluoxetine (FLX) has …

The role of fluoxetine in activating Wnt/β-catenin signaling and repressing β-amyloid production in an Alzheimer mouse model

M Huang, Y Liang, H Chen, B Xu, C Chai… - Frontiers in Aging …, 2018 - frontiersin.org
Fluoxetine (FLX) is one of the selective serotonin reuptake inhibitors (SSRIs)
antidepressants, which could be used to relieve depression and anxiety among AD patients …