Developmental arrest of the preimplantation embryo is a multifactorial condition,
characterized by lack of cellular division for at least 24 hours, hindering the in vitro …

During pre-implantation stages of mammalian development, maternally stored material
promotes both the erasure of the sperm and oocyte epigenetic profiles and is responsible for …

Embryo developmental arrest (EDA) is a cause of infertility. As the assessment of the EDA-
associated phenotypes in situations rather than in vitro fertilization (IVF) is difficult, EDA is …

Embryo development requires orchestrated events, finely regulated at the molecular and
cellular level by mechanisms which are progressively emerging from animal studies. With …

Recent genome-wide omics studies have confirmed the early embryogenesis strictly
dependent on the rigorous spatiotemporal activation and multilevel regulation. However, the …

Background The causes, modes, biological role and prospective significance of cell death in
preimplantation development in humans and other mammals are still poorly understood …

BACKGROUND IVF for the treatment of infertility offers unique opportunities to observe
human preimplantation development. Progress in time-lapse technology (TLT) and …

BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

Human preimplantation embryo development is prone to high rates of early embryo
wastage, particularly under current in vitro culture conditions. There are many possible …

STUDY QUESTION What are the factors associated with human blastocyst spontaneous
collapse and the consequences of this event? SUMMARY ANSWER Approximately 50% of …