Cytokine release from alveolar macrophages exposed to ambient particulate matter: heterogeneity in relation to size, city and season

RB Hetland, FR Cassee, M Låg, M Refsnes… - Particle and fibre …, 2005 - Springer
Background Several studies have demonstrated an association between exposure to
ambient particulate matter (PM) and respiratory and cardiovascular diseases. Inflammation …

Associations of urban air particulate composition with inflammatory and cytotoxic responses in RAW 246.7 cell line

PI Jalava, MR Hirvonen, M Sillanpää… - Inhalation …, 2009 - Taylor & Francis
Epidemiological studies show heterogeneities in the particulate pollution-related exposure–
effect relationships among cardiorespiratory patients, but the connection to chemical …

Determinants of the proinflammatory action of ambient particulate matter in immortalized murine macrophages

C Guastadisegni, FJ Kelly, FR Cassee… - Environmental …, 2010 - ehp.niehs.nih.gov
Background Proximity to traffic-related pollution has been associated with poor respiratory
health in adults and children. Objectives We wished to test the hypothesis that particulate …

Chemical compositions responsible for inflammation and tissue damage in the mouse lung by coarse and fine particulate samples from contrasting air pollution in …

MS Happo, MR Hirvonen, AI Hälinen, PI Jalava… - Inhalation …, 2008 - Taylor & Francis
Inflammation is regarded as an important mechanism in mortality and morbidity associated
with exposures of cardiorespiratory patients to urban air particulate matter. We investigated …

Inflammatory effects of coarse and fine particulate matter in relation to chemical and biological constituents

RPF Schins, JH Lightbody, PJA Borm, T Shi… - Toxicology and applied …, 2004 - Elsevier
There is conflicting evidence in the literature as to the predominant mechanism and also the
compositional element (s) that drives the pulmonary inflammatory response of ambient …

Dose and time dependency of inflammatory responses in the mouse lung to urban air coarse, fine, and ultrafine particles from six European cities

MS Happo, RO Salonen, AI Hälinen, PI Jalava… - Inhalation …, 2007 - Taylor & Francis
We investigated the dose and time dependency of inflammatory and cytotoxic responses to
size-segregated urban air particulate samples in the mouse lung. Coarse (PM10− 2.5), fine …

Particle size, chemical composition, seasons of the year and urban, rural or remote site origins as determinants of biological effects of particulate matter on pulmonary …

MG Perrone, M Gualtieri, V Consonni, L Ferrero… - Environmental …, 2013 - Elsevier
Particulate matter (PM), a complex mix of chemical compounds, results to be associated with
various health effects. However there is still lack of information on the impact of its different …

In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with PM composition, size fraction and oxidative potential-the …

M Steenhof, I Gosens, M Strak, KJ Godri… - Particle and fibre …, 2011 - Springer
Background Ambient particulate matter (PM) exposure is associated with respiratory and
cardiovascular morbidity and mortality. To what extent such effects are different for PM …

Inflammation and tissue damage in mouse lung by single and repeated dosing of urban air coarse and fine particles collected from six European cities

MS Happo, RO Salonen, AI Hälinen, PI Jalava… - Inhalation …, 2010 - Taylor & Francis
The authors have previously demonstrated heterogeneities in the inflammatory activities of
urban air fine (PM2. 5–0.2) and coarse (PM10–2.5) particulate samples collected from six …

Release of inflammatory cytokines, cell toxicity and apoptosis in epithelial lung cells after exposure to ambient air particles of different size fractions

RB Hetland, FR Cassee, M Refsnes, PE Schwarze… - Toxicology in Vitro, 2004 - Elsevier
Several studies have shown that particles of smaller size may be more potent than larger to
induce inflammatory and toxic responses in cultured lung cells. However, the relative …