Can studying cultured cells inform us about the biology of aging? The idea that this may be
was stimulated by the first formal description of replicative senescence. Replicative …

A long-standing controversy concerns the relevance of cellular senescence, defined and
observed as a cell culture phenomenon, to tissue aging in vivo. Here the evidence on this …

Given the duration of ageing in humans, cell culture studies are a promising approach to the
study of human ageing. It is reasonable to assume that human ageing has, at least partly, a …

Normal cells do not divide indefinitely due to a process termed cellular or replicative
senescence. Several lines of evidence suggest that replicative senescence evolved to …

Half a century is fast approaching since Hayflick and colleagues formally described the
limited ability of normal human cells to proliferate in culture (Hayflick and Moorhead, 1961) …

The most common causes of death and suffering, even in most underdeveloped nations, are
age‐related diseases. These diseases share fundamental and often unappreciated …

Cell senescence is the limited ability of primary human cells to divide when cultured in vitro.
This eventual cessation of division is accompanied by a specific set of changes in cell …

Normal cells do not divide indefinitely. This trait, termed the finite replicative life span of cells,
limits the capacity for cell division by a process termed cellular or replicative senescence …

Human cells in culture have a limited proliferative capacity. After a period of vigorous
proliferation, the rate of cell division declines and a number of changes occur in the cells …

The idea that aging is largely the result of (endogeneous) stress appears to be at odds with
the concept of biological 'clocks', which seem to programme and terminate cellular aging …