Mitochondria as a signaling platform play crucial roles in deciding cell fate. Many classic
anticancer agents are known to trigger cell death through induction of mitochondrial …

Many anticancer agents exert cytotoxicity and trigger apoptosis through the induction of
mitochondrial dysfunction. Mitophagy, as a key mitochondrial quality control mechanism …

Mitophagy is a selective form of macroautophagy in which dysfunctional and damaged
mitochondria can be efficiently degraded, removed and recycled through autophagy …

Mitochondria are involved in various biological processes including intracellular
homeostasis, proliferation, senescence, and death, and mitochondrial mitophagy is closely …

Molecules designed to target and accumulate in the mitochondria are an emerging
therapeutic approach for cancer and other indications. Mitochondria-targeted redox agents …

Glioma is difficult-to-treat because of its infiltrative nature and the presence of the blood-
brain barrier. Temozolomide is the only FDA-approved drug for its management. Therefore …

Hepatocellular carcinoma (HCC) remains a major clinical challenge. Although mitophagy is
implicated in hepatocarcinogenesis, novel therapeutic options targeting mitophagy for HCC …

Mutations in the KRAS proto-oncogene are present in 50% of all colorectal cancers and are
increasingly associated with chemotherapeutic resistance to frontline biologic drugs …

Matrine is a natural alkaloid isolated from the root and stem of the legume plant Sophora. Its
anti-proliferative and pro-apoptotic effects on several types of cancer have been well …

Anticancer properties and mechanisms of mimulone (MML), C-geranylflavonoid isolated
from the Paulownia tomentosa fruits, were firstly elucidated in this study. MML prevented cell …