We found that development of obesity was coupled with the emergence of a progressively
worsening brain reward deficit. Similar changes in reward homeostasis induced by cocaine …

We found that development of obesity was coupled with emergence of a progressively
worsening deficit in neural reward responses. Similar changes in reward homeostasis …

Reports an error in" Dopamine D2 receptors in addiction-like reward dysfunction and
compulsive eating in obese rats" by Paul M. Johnson and Paul J. Kenny (Nature …

In 2010, Johnson and Kenny provided conclusive evidence that extended access to a
Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors …

A decrease in D2-like receptor (D2R) binding in the striatum has been reported in obese
individuals and drug addicts. Although natural and drug rewards share neural substrates, it …

The obesity epidemic is believed to be driven by a food environment that promotes
consumption of inexpensive, convenient, high-calorie, palatable foods. Individual …

Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic
dopaminergic pathway. Changes in DA signaling in mesolimbic neurotransmission are …

How can drug addiction help us understand obesity? | Nature Neuroscience Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Background There is increasing evidence that the pathological overeating underlying some
forms of obesity is compulsive in nature and therefore contains elements of an addictive …

Anorexia nervosa (AN) is an eating disorder observed predominantly in women and girls
that is characterized by a low body-mass index, hypophagia, and hyperactivity. Activity …