Mast Cells (MCs) express toll-like receptor 2 (TLR2), a receptor known to be triggered by
several major mycobacterial ligands and involved in resistance against Mycobacterium …

We have previously demonstrated that mycobacterial lipoproteins engage TLR2 on human
CD4+ T cells and upregulate TCR‐triggered IFN‐γ secretion and cell proliferation in vitro …

Endotoxin from Gram-negative bacteria bound to CD14 signals through Toll-like receptor
(TLR) 4, while components of Gram-positive bacteria, fungi, and Mycobacterium tuberculosis …

The role of Toll‐like receptors (TLR) and MyD88 for immune responses to Mycobacterium
tuberculosis (Mtb) infection remains controversial. To address the impact of TLR‐mediated …

Abstract Background. Mast cells (MCs) participate in host resistance to several pathogens,
but little is known about the role played by MCs in Mycobacterium tuberculosis infection …

Tuberculosis causes more annual deaths globally than any other infectious disease.
However, progress in developing novel vaccines, diagnostics, and therapies has been …

Toll-like receptors (TLRs) sense conserved structures of pathogens and influence
macrophage functions. Here we investigated the impact of TLR signaling on the modulation …

Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis, is an
intracellular bacterium capable of surviving and persisting within host mononuclear cells …

Mycobacterium tuberculosis (Mtb), an intracellular pathogen, is phagocytosed by alveolar
macrophage but it is not digested; it survives, proliferates and establishes Mtb infections …

Acute resistance to low dose M. tuberculosis (Mtb) infection is not dependent on Toll-like
receptor (TLR) 2. However, whether TLR2 contributes to resistance in chronic Mtb infection …