A new model of an arteriovenous fistula in chronic kidney disease in the mouse: beneficial effects of upregulated heme oxygenase-1

L Kang, JP Grande, ML Hillestad… - American Journal …, 2016 - journals.physiology.org
The arteriovenous fistula (AVF) is the preferred hemodialysis vascular access, but it is
complicated by high failure rates and attendant morbidity. This study provides the first …

Functioning of an arteriovenous fistula requires heme oxygenase-2

L Kang, JP Grande, G Farrugia… - American Journal …, 2013 - journals.physiology.org
Heme oxygenase-2 (HO-2), the constitutive isoform of the heme-degrading enzyme heme
oxygenase, may serve as an anti-inflammatory vasorelaxant, in part, by generating carbon …

Chronic kidney disease accelerates endothelial barrier dysfunction in a mouse model of an arteriovenous fistula

A Liang, Y Wang, G Han, L Truong… - American Journal of …, 2013 - journals.physiology.org
Hemodialysis patients depend on arteriovenous fistulas (AVF) for vascular access.
Unfortunately, their 2-yr primary patency rate is only 60% because of AVF clog due to intimal …

Regional and systemic hemodynamic responses following the creation of a murine arteriovenous fistula

L Kang, S Yamada, MC Hernandez… - American Journal …, 2011 - journals.physiology.org
The study of hemodynamic alterations following the creation of an arteriovenous fistula
(AVF) is relevant to vascular adaptive responses and hemodialysis access dysfunction. This …

Increased oxidative stress and hypoxia inducible factor-1 expression during arteriovenous fistula maturation

N Sadaghianloo, K Yamamoto, H Bai, M Tsuneki… - Annals of vascular …, 2017 - Elsevier
Background The poor clinical results that are frequently reported for arteriovenous fistulae
(AVF) for hemodialysis are typically due to failure of AVF maturation. We hypothesized that …

[HTML][HTML] Genetic deficiency of heme oxygenase-1 impairs functionality and form of an arteriovenous fistula in the mouse

JP Juncos, MJ Tracz, AJ Croatt, JP Grande… - Kidney international, 2008 - Elsevier
Vascular access dysfunction contributes to patient morbidity during maintenance
hemodialysis. In this study we determined if knockout of heme oxygenase-1 predisposed to …

[HTML][HTML] HOming in on arteriovenous fistula survival

W Durante, CC Lin - Kidney international, 2008 - Elsevier
Vascular access failure is a major clinical problem for patients on hemodialysis, but
therapeutic approaches aimed at improving arteriovenous fistula (AVF) dysfunction remain …

[HTML][HTML] Characterization of neointima lesions associated with arteriovenous fistulas in a mouse model

Y Castier, S Lehoux, Y Hu, G Fonteinos, A Tedgui… - Kidney international, 2006 - Elsevier
Arteriovenous fistulas (AVFs) are usually used for vascular access in the provision of
hemodialysis, but AVFs have a 1-year patency rate of only about 60% owing to stenosis. As …

Hypoxia and hypoxia‐inducible factors promote the development of neointimal hyperplasia in arteriovenous fistula

N Sadaghianloo, J Contenti, S Declemy… - The Journal of …, 2021 - Wiley Online Library
Key points Patients with end‐stage renal failure need arteriovenous fistulas (AVF) to
undergo dialysis. However, AVFs present a high rate of failure as a result of excessive …

[HTML][HTML] Altered hemodynamics during arteriovenous fistula remodeling leads to reduced fistula patency in female mice

T Kudze, S Ono, A Fereydooni, L Gonzalez, T Isaji… - JVS-vascular …, 2020 - Elsevier
Objective The arteriovenous fistula (AVF) is the preferred method of dialysis access because
of its proven superior long-term outcomes. However, women have lower rates of AVF …