With age, haematopoietic stem cells lose their ability to regenerate the blood system, and
promote disease development. Autophagy is associated with health and longevity, and is …

The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-
long production of blood cells. This process requires major molecular adaptations to allow …

Blood production is ensured by rare, self-renewing haematopoietic stem cells (HSCs). How
HSCs accommodate the diverse cellular stresses associated with their life-long activity …

Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle
degradation, with an astonishing number of connections to human disease and physiology …

As malignant tumours develop, they interact intimately with their microenvironment and can
activate autophagy, a catabolic process which provides nutrients during starvation. How …

Autophagy and cancer | Nature Skip to main content Thank you for visiting nature.com. You are
using a browser version with limited support for CSS. To obtain the best experience, we …

Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on
anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy …

Ageing in multicellular organisms typically involves a progressive decline in cell
replacement and repair processes, resulting in several physiological deficiencies, including …

Autophagy is a process of self-cannibalization. Cells capture their own cytoplasm and
organelles and consume them in lysosomes. The resulting breakdown products are inputs to …

Haematopoietic stem cells (HSCs) self-renew for life, thereby making them one of the few
blood cells that truly age,. Paradoxically, although HSCs numerically expand with age, their …