Cutting edge: programmed death-1 up-regulation is involved in the attrition of cytomegalovirus-specific CD8+ T cells in acute self-limited hepatitis B virus infection
Attrition of heterologous virus-specific CD8+ T cells has been demonstrated in murine viral
infection; however, little is known regarding this phenomenon in human viral infections. In …
infection; however, little is known regarding this phenomenon in human viral infections. In …
Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B
Background & Aims: Recent studies have shown that programmed death 1 (PD-1)
expression can impair virus-specific CD8 T-cell responses during chronic viral infection …
expression can impair virus-specific CD8 T-cell responses during chronic viral infection …
Dynamic decrease in PD-1 expression correlates with HBV-specific memory CD8 T-cell development in acute self-limited hepatitis B patients
Z Zhang, B Jin, JY Zhang, B Xu, H Wang, M Shi… - Journal of …, 2009 - Elsevier
BACKGROUND/AIMS: Programmed death-1 (PD-1) upregulation can impair virus-specific
CD8 T-cell responses during chronic viral infection. Whether and how PD-1 affects virus …
CD8 T-cell responses during chronic viral infection. Whether and how PD-1 affects virus …
PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients
G Peng, S Li, W Wu, X Tan, Y Chen, Z Chen - Molecular immunology, 2008 - Elsevier
Programmed death-1 (PD-1) is demonstrated to have an increased expression on antigen-
specific T cells during chronic virus infections, and the blockage of PD-1/PD-ligand (PD-L1) …
specific T cells during chronic virus infections, and the blockage of PD-1/PD-ligand (PD-L1) …
Clinical Significance of Dynamics of Programmed Death Ligand-1 Expression on Circulating CD14+ Monocytes and CD19+ B Cells with the Progression of Hepatitis …
ZY Huang, P Xu, JH Li, CH Zeng, HF Song… - Viral …, 2017 - liebertpub.com
Abstract Programmed death-1 (PD-1) expression has been revealed to be upregulated on T
cells and contributes to T cell exhaustion in patients with hepatitis B virus (HBV) infection. In …
cells and contributes to T cell exhaustion in patients with hepatitis B virus (HBV) infection. In …
Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
N Nakamoto, DE Kaplan, J Coleclough, Y Li, ME Valiga… - Gastroenterology, 2008 - Elsevier
BACKGROUND & AIMS: The immunoinhibitory receptor programmed death 1 (PD-1) is up-
regulated on dysfunctional virus-specific CD8 T cells during chronic viral infections, and …
regulated on dysfunctional virus-specific CD8 T cells during chronic viral infections, and …
[HTML][HTML] HBcAg induces PD-1 upregulation on CD4+ T cells through activation of JNK, ERK and PI3K/AKT pathways in chronic hepatitis-B-infected patients
M Li, XH Sun, XJ Zhu, SG Jin, ZJ Zeng, ZH Zhou… - Laboratory …, 2012 - Elsevier
Hyper-expression of programmed death-1 (PD-1) is a hallmark of exhausted T cells. In
chronic hepatitis-B virus (HBV)-infected patients, PD-1 upregulation on T cells was often …
chronic hepatitis-B virus (HBV)-infected patients, PD-1 upregulation on T cells was often …
[HTML][HTML] The expression of programmed death-1 in circulating CD4+ and CD8+ T cells during hepatitis B virus infection progression and its correlation with clinical …
P Xu, YJ Chen, H Chen, XY Zhu, HF Song, LJ Cao… - Gut and liver, 2014 - ncbi.nlm.nih.gov
Methods PD-1 expression in circulating CD4+ and CD8+ T cells was detected by flow
cytometry. The correlations between PD-1 expression and HBV viral load, alanine …
cytometry. The correlations between PD-1 expression and HBV viral load, alanine …
[HTML][HTML] Natural course of chronic hepatitis B is characterized by changing patterns of programmed death type-1 of CD8-positive T cells
XS Liang, Y Zhou, CZ Li, MB Wan - World journal of …, 2010 - ncbi.nlm.nih.gov
AIM: To investigate if and how programmed death type-1 (PD-1) expression affects the
natural course of hepatitis B virus (HBV) infection. METHODS: Sixty-four patients in different …
natural course of hepatitis B virus (HBV) infection. METHODS: Sixty-four patients in different …
Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection
C Boni, P Fisicaro, C Valdatta, B Amadei… - Journal of …, 2007 - Am Soc Microbiol
Dysfunctional CD8+ T cells present in chronic virus infections can express programmed
death 1 (PD-1) molecules, and the inhibition of the engagement of PD-1 with its ligand (PD …
death 1 (PD-1) molecules, and the inhibition of the engagement of PD-1 with its ligand (PD …