Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of
maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily …

Estrogens and estrogen metabolites have important functions in cardiovascular and other
physiology, yet the patterns of estrogen synthesis, metabolism, and the individual plasma …

Introduction Estrogens and progesterone play critical roles in angiogenesis and
vasodilation. Moreover, placental aromatase deficiency is detected in women with …

OBJECTIVE: Experimental data have revealed the critical role played by 2-methoxy-
estradiol, a metabolite of 17β-estradiol, in the pathophysiology of preeclampsia. We used …

Preeclampsia (PE) is a pregnancy-specific syndrome and one of the leading causes of
preterm birth, neonatal and maternal morbidity and mortality. This disease is characterized …

Introduction Preeclampsia is a maternal hypertensive disorder with uncertain etiology and a
leading cause of maternal and fetal mortality worldwide, causing nearly 40% of premature …

Abnormalities in the development of placental vasculature in early pregnancy and the failure
of transformation of the spiral arteries are associated with the pathogenesis of preeclampsia …

Pre‐eclampsia is a pregnancy specific syndrome that is a principal cause of maternal
morbidity and mortality, accounting for almost 15% of pregnancy associated deaths, and is …

Objective: To determine the effects of fetal sex on aromatase and androgen receptor (AR)
expression in the placenta of normal and preeclamptic pregnancies. Study Design …

Preeclampsia is a multisystem disorder of pregnancy that remains a leading cause of
maternal and foetal morbidity and mortality. It is still an underestimated risk factor for future …