This study aimed to deliver a potential water-soluble antiviral drug (sofosbuvir) through
optimized vesicular lipid nanocarriers (LNs) to the rat brain as a novel strategy against viral …

The current research work entails the formulation, optimization and evaluation of nanolipidic
carriers of an antiretroviral drug, lopinavir for brain targeting to reduce HIV associated …

Purpose: As an anti-retroviral Protease Inhibitor (PI), Indinavir (IDV) is part of the regimen
known as Highly Active Anti-Retroviral Therapy (HAART) widely used for Human …

Background: Protease inhibitors such as lopinavir have negligible permeability to the CNS
due to blood–brain and blood–cerebrospinal fluid interfaces. An attempt has been made to …

Cholesterol‐mediated cationic solid lipid nanoparticles (CSLNs) were formulated with
esterquat 1 (EQ 1) and stearylamine as positively charged external layers on hydrophobic …

Nanostructured lipid carriers (NLCs) loaded with lopinavir (LPV) were prepared by the high-
shear homogenization method. The LPV-NLCs formulations were freeze-dried using …

Intranasal delivery is a potential platform that can be employed in targeting the antiretrovirals
(ARVs) to reach HIV that harbors in the central nervous system. The objective of the study …

Brain is one of the dominant reservoirs of HIV. Blood Brain Barrier (BBB) provides a great
challenge in the delivery of Tenofovir disoproxil fumerate (TDF) to CNS after systemic …

Introduction: At the end of 2014, almost 36.9 million people were living with HIV which has
put the HIV infection in the list of major public health issues. Although almost thirty drugs are …

Aims Herein, we investigate the potential of levosulpiride-loaded nanostructured lipid
carriers (LEVO-NLCs) for effective brain delivery with anti-psychotic and antidepressant …