Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome

K Röltgen, AE Powell, OF Wirz, BA Stevens… - Science …, 2020 - science.org
SARS-CoV-2-specific antibodies, particularly those preventing viral spike receptor binding
domain (RBD) interaction with host angiotensin-converting enzyme 2 (ACE2) receptor, can …

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization

E Salazar, SV Kuchipudi… - The Journal of …, 2020 - Am Soc Clin Investig
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
highlights the urgent need for assays that detect protective levels of neutralizing antibodies …

Sequential analysis of binding and neutralizing antibody in COVID-19 convalescent patients at 14 months after SARS-CoV-2 infection

M Rosati, E Terpos, I Ntanasis-Stathopoulos… - Frontiers in …, 2021 - frontiersin.org
Durability of SARS-CoV-2 Spike antibody responses after infection provides information
relevant to understanding protection against COVID-19 in humans. We report the results of a …

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

AS Iyer, FK Jones, A Nodoushani, M Kelly… - Science …, 2020 - science.org
We measured plasma and/or serum antibody responses to the receptor-binding domain
(RBD) of the spike (S) protein of SARS-CoV-2 in 343 North American patients infected with …

Breadth and function of antibody response to acute SARS-CoV-2 infection in humans

KYA Huang, TK Tan, TH Chen, CG Huang… - Plos …, 2021 - journals.plos.org
Serological and plasmablast responses and plasmablast-derived IgG monoclonal
antibodies (MAbs) have been analysed in three COVID-19 patients with different clinical …

[HTML][HTML] Relationship between anti-spike protein antibody titers and SARS-CoV-2 in vitro virus neutralization in convalescent plasma

E Salazar, SV Kuchipudi, PA Christensen, TN Eagar… - biorxiv, 2020 - ncbi.nlm.nih.gov
Newly emerged pathogens such as SARS-CoV-2 highlight the urgent need for assays that
detect levels of neutralizing antibodies that may be protective. We studied the relationship …

COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain

M Secchi, E Bazzigaluppi, C Brigatti… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Serological assays are of critical importance to investigate correlates of
response and protection in coronavirus disease 2019 (COVID-19), to define previous …

Competitive SARS-CoV-2 serology reveals most antibodies targeting the spike receptor-binding domain compete for ACE2 binding

JR Byrnes, XX Zhou, I Lui, SK Elledge, JE Glasgow… - MSphere, 2020 - Am Soc Microbiol
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread
around the world, there is an urgent need for new assay formats to characterize the humoral …

Magnitude and kinetics of anti–severe acute respiratory syndrome coronavirus 2 antibody responses and their relationship to disease severity

KL Lynch, JD Whitman, NP Lacanienta… - Clinical Infectious …, 2021 - academic.oup.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can
be detected indirectly by measuring the host immune response. For some viruses, antibody …

Discrete SARS-CoV-2 antibody titers track with functional humoral stability

YC Bartsch, S Fischinger, SM Siddiqui, Z Chen… - Nature …, 2021 - nature.com
Antibodies serve as biomarkers of infection, but if sustained can confer long-term immunity.
Yet, for most clinically approved vaccines, binding antibody titers only serve as a surrogate …