Abstract The REL/NF-κB/IκB superfamily of signal transducers and transcription factors are
paradigmatic of molecular mechanisms by which rapid responses in the immune system can …

Publisher Summary This chapter focuses on the REL/NF-κB/IKB story. NF-κB is a
transcription factor first identified as a lymphoid-specific protein that binds to a decameric …

During their lifetime, cells encounter many life or death situations that challenge their very
own existence. Their survival depends on the interplay within a complex yet precisely …

▪ Abstract The transcription factor NF-κB, more than a decade after its discovery, remains an
exciting and active area of study. The involvement of NF-κB in the expression of numerous …

Complexes formed from the nuclear factor κB (NF-κB) family of transcription factors are
ubiquitously expressed and are induced by a diverse array of stimuli. This results in their …

Recent progress in the identification and functional analysis of protein kinases and adapter
molecules that lead to activation of NF-κB family transcription factors has lead to a quite …

In mammals, Rel/NF-κB proteins are a small family of transcription factors which serve as
pivotal regulators of immune, inflammatory and acute phase responses. Pathways leading to …

In the 25 years since its discovery, the nuclear factor-κB (NF-κB) family of transcription
factors has been the subject of intensive research in virtually all areas of biomedical science …

One of the primary physiological roles of nuclear factor-kappa B (NF-κB) is in the immune
system. In particular, NF-κB family members control the transcription of cytokines and …

The nuclear factor-κB (NF-κB)/REL family of transcription factors has a central role in
coordinating the expression of a wide variety of genes that control immune responses. There …