Background The inverse relationship between exercise capacity and its variation over time
and both cardiovascular and all-cause mortality suggests the existence of an etiological …

OBJECTIVES: In the present study, we investigated whether replacement of tap water by
fructose or sucrose solutions affect rat body weight and insulin action in skeletal muscles …

Over the past decades, obesity and its metabolic co-morbidities such as type 2 diabetes
(T2D) developed to reach an endemic scale. However, the mechanisms leading to the …

Metabolic syndrome components, including obesity, dyslipidemia and impaired glucose
homeostasis, become a major public health issue. Muscles play a predominant role in …

Apoptosis and autophagy are critical in normal skeletal muscle homeostasis; however,
dysregulation can lead to muscle atrophy and dysfunction. Lipotoxicity and/or lipid …

Insulin resistance and muscle mass loss often coincide in individuals with type 2 diabetes.
Most patients with type 2 diabetes are overweight, and it is well established that obesity and …

Intramyocellular lipid content (IMCL) serves as a good biomarker of skeletal muscle insulin
resistance (IR). However, intracellular fatty acid metabolites [malonyl-CoA, long-chain acyl …

Aims/hypothesis Intramyocellular lipids (IMCL) accumulation is a classical feature of
metabolic diseases. We hypothesised that IMCL accumulate mainly as a consequence of …

Skeletal muscle autophagy is suppressed by insulin, but it is not clear if such suppression is
altered with insulin resistance. We investigated if the inhibitory action of insulin on …

The physiological dynamics of intramyocellular lipids (IMCLs) in different muscle types and
of hepatocellular lipids (HepCLs) are still uncertain. The dynamics of IMCLs in the soleus …