Vertebrate animals have developed sophisticated host defense mechanisms against
potentially hostile antigens. These mechanisms mainly involve the immune system and the …

Immune cells are part of the most dynamic organ system in the body, which fights primarily
against infections and maintains cellular integrity and homeostasis. Memory is a unique …

Innate immune cells form a first line of defense against invading pathogens. It comprises a
variety of cells including neutrophils, natural killer cells (NK), and macrophages and their …

Significance: A growing body of clinical and experimental evidence has challenged the
traditional understanding that only the adaptive immune system can mount immunological …

The immune response must balance the pro-inflammatory, cell-mediated cytotoxicity with the
anti-inflammatory and wound repair response. Epigenetic mechanisms mediate this balance …

Epigenetic modification of cellular genomes is a fascinating means of regulating tissue-and
cell type-specific gene expression in all developmental stages of the life of an organism …

The natural fastest way to deal with pathogens or danger signals is the innate immune
system. This system prevents too much inflammation and tissue damage and efficiently …

Inflammation is a fundamental biologic process that is evolutionally conserved by a germ
line code. The interplay between epigenetics and environment directs the code into …

The cells within the immune system differentiate from a common precursor and need to be
poised for rapid function after foreign insult, without responding to self. This response must …

Highlights•Chromatin dynamics regulate pattern, timing and magnitude of gene
expression.•Signal transduction downstream of TLR4 regulate histones for inducible gene …