Murine experimental autoimmune encephalomyelitis is a well-established model that
recapitulates many clinical and physiopathological aspects of multiple sclerosis (MS). An …

The immune system is highly diverse, but characterization of its genetic architecture has
lagged behind the vast progress made by genome-wide association studies (GWASs) of …

Epigenetic modifications, such as histone modifications, DNA methylation status, and non-
coding RNAs (ncRNA), all contribute to antibody maturation during somatic hypermutation …

The last few years have witnessed an increasing body of evidence that challenges the
traditional view that immunological memory is an exclusive trait of the adaptive immune …

Fighting pathogens and maintaining tissue homeostasis are prerequisites for survival. Both
of these functions are upheld by the immune system, though the latter is often overlooked in …

Inflammation and immune response play a pivotal role in the pathophysiology of ischemic
stroke giving their contribution to tissue damage and repair. Emerging evidence supports the …

Immune cells are pivotal in the reaction to injury, whereupon, under ideal conditions, repair
and resolution phases restore homeostasis following initial acute inflammation. Immune cell …

Effects of Infection on Natural Immunity Antigen-nonspecific host defenses are altered by
infections, with epigenetic changes in the effector cells of natural immunity. Some of these …

There are no existing treatments for the long-term degenerative effects of traumatic brain
injury (TBI). This is due, in part, to our limited understanding of chronic TBI and uncertainty …

Epigenetic alterations are necessary for the establishment of functional and phenotypic
diversity in the populations of immune cells of the monocytic lineage. The epigenetic status …