The past decade has seen an explosion of interest for understanding epigenetic
mechanisms. This is not surprising since it has been obvious that we need this knowledge to …

Adoptive transfer experimental autoimmune encephalomyelitis (AT-EAE) is an inflammatory
demyelination that recapitulates in mouse spinal cord (SC) the human multiple sclerosis …

Protective immune responses in the central nervous system (CNS) must act efficiently but
need to be tightly controlled to avoid excessive damage to this vital organ. Under …

The experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease of the
central nervous system commonly used to study multiple sclerosis (MS). We combined …

Stroke is a leading contributor of death and disability around the world. Despite its
recognised debilitating neurological deficits, a devastating clinical complication of surviving …

Hematopoietic stem cells (HSCs) maintain life-long production of immune cells and can
directly respond to infection, but sustained effects on the immune response remain unclear …

Background Monocytes are key mediators of innate immunity to infection, undergoing
profound and dynamic changes in epigenetic state and immune function which are broadly …

Human innate immune cells exposed to certain infections or stimuli develop enhanced
immune responses upon re-infection with a different second stimulus, a process termed …

Epigenetic modification is an additional regulator in immune responses as the genome-wide
profiling somehow fails to explain the sophisticated mechanisms in autoimmune diseases …

Various cellular processes including the pathogen-specific immune responses, host–
pathogen interactions and the related evasion mechanisms rely on the ability of the immune …