Iron is essential to all microorganisms. To obtain iron from the very low concentrations
present in their environment, microorganisms have developed sophisticated mechanisms …

During infection microbes attack host tissues, causing damage to specific organs, sepsis or
even death. For proliferation microbes desperately need iron for which they have to compete …

Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both
invading pathogens and mammalian cells including those of the immune system require iron …

My laboratory has been interested for some time in the influence of iron, a nutrient that is
essential for both microbial pathogens and their mammalian hosts, on the course of …

Host antimicrobial mechanisms reduce iron availability to pathogens. Iron proteins
influencing the innate immune response include hepcidin, lactoferrin, siderocalin …

The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic
microorganisms and their hosts. It is also a pivotal component of the innate immune …

The acute-phase response is triggered by the presence of infectious agents and danger
signals which indicate hazards for the integrity of the mammalian body. One central feature …

The data on the relationship between iron deficiency and infection are conflicting. Some
researchers conclude that mild iron deficiency is beneficial for immunity, whereas others …

Iron is essential for nearly all living organisms. Innate immunity effectively restricts iron
availability to microbial invaders. Some microbes have evolved effective countermeasures …

The iron-binding proteins transferrin and lactoferrin restrict the amount of ionic iron available
in body fluids to 10-18 M. This amount is insufficient for normal bacterial growth, and …