The α7β1-integrin increases muscle hypertrophy following multiple bouts of eccentric exercise

K Zou, BM Meador, B Johnson… - Journal of Applied …, 2011 - journals.physiology.org
Mechanical stimuli increase skeletal muscle growth in a mammalian target of rapamycin
(mTOR)-and p70S6K-dependent manner. It has been proposed that costameric proteins at Z …

The α7β1-integrin accelerates fiber hypertrophy and myogenesis following a single bout of eccentric exercise

TN Lueders, K Zou, HD Huntsman… - … of physiology-cell …, 2011 - journals.physiology.org
The α7β1-integrin is a heterodimeric transmembrane protein that adheres to laminin in the
extracellular matrix, representing a critical link that maintains structure in skeletal muscle. In …

Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy

MD Boppart, ZS Mahmassani - American Journal of …, 2019 - journals.physiology.org
The α7β1-integrin is a transmembrane adhesion protein that connects laminin in the
extracellular matrix (ECM) with actin in skeletal muscle fibers. The α7β1-integrin is highly …

α7β1-Integrin regulates mechanotransduction and prevents skeletal muscle injury

MD Boppart, DJ Burkin… - American Journal of …, 2006 - journals.physiology.org
α7β1-Integrin links laminin in the extracellular matrix with the cell cytoskeleton and therein
mediates transduction of mechanical forces into chemical signals. Muscle contraction and …

β2-Integrins contribute to skeletal muscle hypertrophy in mice

JS Marino, BJ Tausch, CL Dearth… - … of Physiology-Cell …, 2008 - journals.physiology.org
We tested the contribution of β2-integrins, which are important for normal function of
neutrophils and macrophages, to skeletal muscle hypertrophy after mechanical loading …

Mesenchymal stem cells contribute to vascular growth in skeletal muscle in response to eccentric exercise

HD Huntsman, N Zachwieja, K Zou… - … of physiology-heart …, 2013 - journals.physiology.org
The α7β1-integrin is an adhesion molecule highly expressed in skeletal muscle that can
enhance regeneration in response to eccentric exercise. We have demonstrated that …

Exercise promotes α7 integrin gene transcription and protection of skeletal muscle

MD Boppart, SE Volker, N Alexander… - American journal …, 2008 - journals.physiology.org
The α7β1 integrin is increased in skeletal muscle in response to injury-producing exercise,
and transgenic overexpression of this integrin in mice protects against exercise-induced …

[PDF][PDF] Mesenchymal stem cells augment the adaptive response to eccentric exercise

K Zou, HD Huntsman, MC Valero, J Adams… - Med Sci Sports …, 2015 - researchgate.net
2015. Purpose: The> 7A1 integrin is a transmembrane protein expressed in the skeletal
muscle that can link the actin cytoskeleton to the surrounding basal lamina. We have …

Increasing α7β1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression

J Liu, DJ Burkin, SJ Kaufman - American Journal of …, 2008 - journals.physiology.org
The dystrophin-glycoprotein complex maintains the integrity of skeletal muscle by
associating laminin in the extracellular matrix with the actin cytoskeleton. Several human …

Integrin signaling's potential for mediating gene expression in hypertrophying skeletal muscle

JA Carson, L Wei - Journal of applied physiology, 2000 - journals.physiology.org
Overloaded skeletal muscle undergoes dramatic shifts in gene expression, which alter both
the phenotype and mass. Molecular biology techniques employing both in vivo and in vitro …