Myocardial ischemia reperfusion injury contributes to adverse cardiovascular outcomes after
myocardial ischemia, cardiac surgery or circulatory arrest. Primarily, no blood flow to the …

Prompt reperfusion therapy in acute myocardial infarction enhances clinical outcome.
However, reperfusion itself may contribute to myocardial cell death. The current review …

Cardiomyocyte death secondary to transient ischemia occurs mainly during the first minutes
of reperfusion, in the form of contraction band necrosis involving sarcolemmal rupture …

Lack of blood supply or ischaemia underlies many of the most important cardiovascular and
cerebrovascular diseases faced by clinicians in their daily practice. Many of these ischaemic …

Effective primary and secondary prevention and advances in cardiac surgery have
significantly improved the care and outcomes of patients with myocardial ischemia. While …

Since the initial description of the phenomenon by Jennings et al 50 years ago, our
understanding of the underlying mechanisms of reperfusion injury has grown significantly …

Lethal reperfusion injury is a paradoxical type of myocardial injury caused by the restoration
of coronary blood flow after an ischemic episode. This review focuses on the mechanisms of …

The damage inflicted on the myocardium during acute myocardial infarction is the result of 2
processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the …

Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In
patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and …

Animal models of sustained ischemia have shown exacerbation of myocardial injury during
reperfusion, mediated largely by cytotoxic effects of free radical generation, complement …