Insulin resistance is a characteristic feature of type 2 diabetes mellitus, obesity, and the
metabolic syndrome. Increased intracellular fat content in skeletal muscle and liver …

Insulin resistance in skeletal muscle is a major hallmark of type 2 diabetes mellitus (T2D)
and obesity that is characterized by impaired insulin-mediated glucose transport and …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …

Insulin resistance is a key defect associated with obesity and type-2 diabetes. The precise
factors that lead to insulin resistance have not been elucidated fully, but there is a strong …

Insulin resistance plays a major role in the pathogenesis of the metabolic syndrome and
type 2 diabetes, and yet the mechanisms responsible for it remain poorly understood …

The precise cause of insulin resistance and type 2 diabetes is unknown. However, there is a
strong association between insulin resistance and lipid accumulation—and, in particular …

Multiple organs contribute to the development of peripheral insulin resistance, with the major
contributors being skeletal muscle, liver, and adipose tissue. Because insulin resistance …

The specific cellular underpinnings or mechanisms of insulin resistance (IR) are not clear.
Here I present evidence to support a causal association between mitochondrial energetics …

As a major site of glucose uptake following a meal, skeletal muscle has an important role in
whole-body glucose metabolism. Evidence in humans and animal models of insulin …

Abundant evidence has been accumulated to suggest that mitochondrial dysfunction is
associated with type 2 diabetes. Research findings from this and other laboratories have …