Methods The Cal-PAT study is a multi-centered, prospective, observational cohort study with
a retrospective comparison. From March 2015 to July 2017, patients≥ 18 years-old who …

The utilization of tranexamic acid (TXA) for the management of bleeding trauma patients has
been a subject of much debate on both sides of the Atlantic and in Australia. As a result of …

Many trauma systems are examining whether to implement prehospital tranexamic acid
(TXA) protocols since hemorrhage remains the leading cause of potentially preventable …

Methods This is an ongoing multi-centered, prospective, observational cohort study with a
retrospective chart-review comparison. Trauma patients identified in the prehospital setting …

Hemorrhage and coagulopathy remain major drivers of early preventable mortality in military
and civilian trauma. The development of trauma-induced coagulopathy and hyperfibrinolysis …

Background The leading cause of preventable death in the military setting is haemorrhage.
Accumulating evidence has established the benefit of tranexamic acid (TXA), an …

Background Tranexamic acid (TXA) has been shown to reduce mortality in the treatment of
traumatic hemorrhage. This effect seems most profound when given early after injury. We …

Purpose The purpose of this study was to test the efficacy of prehospital administration of
tranexamic acid (TXA) to injured patients on mortality, thromboembolic events and need for …

The CRASH-2 trial results have prompted trauma centers to contemplate whether
tranexamic acid (TXA) should be added to their armamentarium for the treatment of bleeding …

Objective: To characterize the relationship between tranexamic acid (TXA) use and patient
outcomes in a severely injured civilian cohort, and to determine any differential effect …