Nanosized phase segregation of sphingomyelin and dihydrosphigomyelin in unsaturated phosphatidylcholine binary membranes without cholesterol

T Yasuda, JP Slotte, M Murata - Langmuir, 2018 - ACS Publications
In this study, we applied fluorescence spectroscopy, differential scanning calorimetry (DSC),
and 2H NMR to elucidate the properties of nanoscopic segregated domains in …

Impact of sphingomyelin acyl chain heterogeneity upon properties of raft-like membranes

K Hirano, M Kinoshita, N Matsumori - Biochimica et Biophysica Acta (BBA) …, 2022 - Elsevier
Sphingomyelin (SM) is a main component of lipid rafts and characteristic of abundance of
long and saturated acyl chains. Recently, we reported that fluorescence-labeled lipids …

[HTML][HTML] Gel-gel phase separation within milk sphingomyelin domains revealed at the nanoscale using atomic force microscopy

F Guyomarc'h, M Chen, O Et-Thakafy, S Zou… - Biochimica et Biophysica …, 2017 - Elsevier
The milk sphingomyelin (MSM) is involved in the formation of ordered lipid domains in the
biological milk fat globule membrane (MFGM), where it accounts for about 30% wt of the …

Sphingomyelin in high-density lipoproteins: structural role and biological function

R Martínez-Beamonte, JM Lou-Bonafonte… - International journal of …, 2013 - mdpi.com
High-density lipoprotein (HDL) levels are an inverse risk factor for cardiovascular diseases,
and sphingomyelin (SM) is the second most abundant phospholipid component and the …

[HTML][HTML] Conformational studies of sphingolipids by NMR spectroscopy. II. Sphingomyelin

CM Talbott, I Vorobyov, D Borchman, KG Taylor… - … et Biophysica Acta (BBA …, 2000 - Elsevier
Sphingomyelin (SM) is the most prevalent sphingolipid in the majority of mammalian
membranes. Proton and 31P nuclear magnetic resonance spectral data were acquired to …

[HTML][HTML] Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner

T Róg, A Orłowski, A Llorente, T Skotland… - … et Biophysica Acta (BBA …, 2016 - Elsevier
It has been a long-standing question how the two leaflets in a lipid bilayer modulate each
others' physical properties. In this paper, we discuss how this interaction may take place …

Interactions of N-stearoyl sphingomyelin with cholesterol and dipalmitoylphosphatidylcholine in bilayer membranes

PR Maulik, GG Shipley - Biophysical journal, 1996 - cell.com
Differential scanning calorimetry and x-ray diffraction have been utilized to investigate the
interaction of N-stearoylsphingomyelin (C18: 0-SM) with cholesterol and …

Comprehensive molecular motion capture for sphingomyelin by site-specific deuterium labeling

N Matsumori, T Yasuda, H Okazaki, T Suzuki… - Biochemistry, 2012 - ACS Publications
Lipid rafts have attracted much attention because of their significant functional roles in
membrane-associated processes. It is thought that sphingomyelin and cholesterol are …

Cholesterol decreases the interfacial elasticity and detergent solubility of sphingomyelins

XM Li, MM Momsen, JM Smaby, HL Brockman… - Biochemistry, 2001 - ACS Publications
The interfacial interactions of cholesterol with sphingomyelins (SMs) containing various
homogeneous acyl chains have been investigated by Langmuir film balance approaches …

Resolving Modifications on Sphingoid Base and N-Acyl Chain of Sphingomyelin Lipids in Complex Lipid Extracts

X Zhao, G Wu, W Zhang, M Dong, Y Xia - Analytical Chemistry, 2020 - ACS Publications
Sphingomyelins (SMs) are an essential class of lipids widely existing in different organisms.
The sphingoid base and N-acyl chain are two building blocks which can undergo different …