Background Mutations in BRCA1 or BRCA2 genes results in an elevated risk for developing
both breast and ovarian cancers over the lifetime of affected carriers. General surgeons may …

Background Advances in understanding molecular and genetic mechanisms underlying
cancer promise an “individualized” management of the disease. Women with a BRCA1 or …

Context Mastectomy and salpingo-oophorectomy are widely used by carriers of BRCA1 or
BRCA2 mutations to reduce their risks of breast and ovarian cancer. Objective To estimate …

Background Women who have inherited mutations in the BRCA1 or BRCA2 genes have
substantially elevated risks of breast and ovarian cancer. Mutation carriers have various …

OBJECTIVE: Despite substantial survival benefits of risk-reducing mastectomy (RRM) and
risk-reducing bilateral salpingo-oophorectomy (RRBSO) among BRCA mutation carriers …

Purpose: To systematically investigate the effectiveness of prophylactic surgeries (PS)
implemented in women carrying BRCA1/2 mutations. Experimental Design: The PubMed …

Purpose Data on the efficacy of bilateral prophylactic mastectomy for breast cancer risk
reduction in women with BRCA1 and BRCA2 (BRCA1/2) mutations are limited, despite the …

Background Risk-reducing salpingo-oophorectomy (RRSO) is widely used by carriers of
BRCA1 or BRCA2 (BRCA1/2) mutations to reduce their risks of breast and ovarian cancer …

BACKGROUND: The availability of genetic testing for inherited mutations in the BRCA1
gene provides potentially valuable information to women at high risk of breast or ovarian …

Background Women with BRCA1 or BRCA2 mutations have an increased risk of breast
cancer and ovarian cancer. Prophylactic mastectomy and oophorectomy are often …