Risk reduction and survival benefit of prophylactic surgery in BRCA mutation carriers, a systematic review
KK Ludwig, J Neuner, A Butler, JL Geurts… - The American Journal of …, 2016 - Elsevier
Background Mutations in BRCA1 or BRCA2 genes results in an elevated risk for developing
both breast and ovarian cancers over the lifetime of affected carriers. General surgeons may …
both breast and ovarian cancers over the lifetime of affected carriers. General surgeons may …
The Predominant Role of Surgery in the Prevention and New Trends in the Surgical Treatment of Women With BRCA1/2 Mutations
M Fatouros, G Baltoyiannis, DH Roukos - Annals of surgical oncology, 2008 - Springer
Background Advances in understanding molecular and genetic mechanisms underlying
cancer promise an “individualized” management of the disease. Women with a BRCA1 or …
cancer promise an “individualized” management of the disease. Women with a BRCA1 or …
Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality
Context Mastectomy and salpingo-oophorectomy are widely used by carriers of BRCA1 or
BRCA2 mutations to reduce their risks of breast and ovarian cancer. Objective To estimate …
BRCA2 mutations to reduce their risks of breast and ovarian cancer. Objective To estimate …
Risk-reducing strategies for women carrying BRCA1/2 mutations with a focus on prophylactic surgery
M Salhab, S Bismohun, K Mokbel - BMC women's health, 2010 - Springer
Background Women who have inherited mutations in the BRCA1 or BRCA2 genes have
substantially elevated risks of breast and ovarian cancer. Mutation carriers have various …
substantially elevated risks of breast and ovarian cancer. Mutation carriers have various …
Impact of family history on choosing risk-reducing surgery among BRCA mutation carriers
K Singh, J Lester, B Karlan, C Bresee, T Geva… - American journal of …, 2013 - Elsevier
OBJECTIVE: Despite substantial survival benefits of risk-reducing mastectomy (RRM) and
risk-reducing bilateral salpingo-oophorectomy (RRBSO) among BRCA mutation carriers …
risk-reducing bilateral salpingo-oophorectomy (RRBSO) among BRCA mutation carriers …
Effectiveness of Prophylactic Surgeries in BRCA1 or BRCA2 Mutation Carriers: A Meta-analysis and Systematic Review
X Li, R You, X Wang, C Liu, Z Xu, J Zhou, B Yu… - Clinical Cancer …, 2016 - AACR
Purpose: To systematically investigate the effectiveness of prophylactic surgeries (PS)
implemented in women carrying BRCA1/2 mutations. Experimental Design: The PubMed …
implemented in women carrying BRCA1/2 mutations. Experimental Design: The PubMed …
Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group
TR Rebbeck, T Friebel, HT Lynch… - Journal of clinical …, 2004 - ascopubs.org
Purpose Data on the efficacy of bilateral prophylactic mastectomy for breast cancer risk
reduction in women with BRCA1 and BRCA2 (BRCA1/2) mutations are limited, despite the …
reduction in women with BRCA1 and BRCA2 (BRCA1/2) mutations are limited, despite the …
Meta-analysis of Risk Reduction Estimates Associated With Risk-Reducing Salpingo-oophorectomy in BRCA1 or BRCA2 Mutation Carriers
TR Rebbeck, ND Kauff… - Journal of the National …, 2009 - academic.oup.com
Background Risk-reducing salpingo-oophorectomy (RRSO) is widely used by carriers of
BRCA1 or BRCA2 (BRCA1/2) mutations to reduce their risks of breast and ovarian cancer …
BRCA1 or BRCA2 (BRCA1/2) mutations to reduce their risks of breast and ovarian cancer …
Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers
TR Rebbeck, AM Levin, A Eisen… - Journal of the …, 1999 - academic.oup.com
BACKGROUND: The availability of genetic testing for inherited mutations in the BRCA1
gene provides potentially valuable information to women at high risk of breast or ovarian …
gene provides potentially valuable information to women at high risk of breast or ovarian …
Decision Analysis — Effects of Prophylactic Mastectomy and Oophorectomy on Life Expectancy among Women with BRCA1 or BRCA2 Mutations
Background Women with BRCA1 or BRCA2 mutations have an increased risk of breast
cancer and ovarian cancer. Prophylactic mastectomy and oophorectomy are often …
cancer and ovarian cancer. Prophylactic mastectomy and oophorectomy are often …
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