Relapse to cocaine-seeking behavior requires an increase in nucleus accumbens (NAc)
core glutamate transmission. Decreased expression of glutamate type I transporter (GLT1) …

Cocaine addiction is characterized by compulsive drug seeking, including relapse after a
period of withdrawal. The relapse response requires increased glutamate transmission in …

Cocaine use disorder is a chronically relapsing disease without FDA-approved treatments.
Using a rodent model of cocaine relapse, we and others have previously demonstrated that …

Glutamate transmission is an important mediator of the development of substance use
disorders, particularly with regard to relapse. The present review summarizes the changes in …

Relapse to cocaine-seeking behavior depends on increased glutamate transmission in key
regions of the mesocorticolimbic motive circuit, including prefrontal cortex (PFC) and …

Downregulation of the astroglial glutamate transporter GLT-1 is observed in the nucleus
accumbens (NAc) following administration of multiple drugs of abuse. The decrease in GLT …

Glutamatergic system has an important role in cocaine-seeking behavior. Studies have
reported that chronic exposure to cocaine induces downregulation of glutamate transporter …

BACKGROUND: The cystine-glutamate exchanger is downregulated after chronic cocaine,
resulting in reduced extracellular levels of nucleus accumbens glutamate. The importance of …

There are currently no FDA-approved medications to reduce cocaine relapse. The majority
of preclinical studies aimed at identifying the neurobiology underlying relapse involve the …

Both pre‐clinical and clinical studies indicate that N‐acetylcysteine (NAC) may be useful in
treating relapse to addictive drug use. Cocaine self‐administration in rats reduces both …