Different neurotransmitter systems are involved in behavioural and molecular responses to
morphine. The brain stress system is activated by acute administration of drugs of abuse …

Corticotropin-releasing factor (CRF) acts as neuro-regulator of the behavioral and emotional
integration of environmental and endogenous stimuli associated with drug dependence …

Rationale Evidence suggests that corticotropin-releasing factor (CRF) system is an important
mediator in the negative symptoms of opioid withdrawal. Objectives We used genetically …

The possible effect of different corticotropin-releasing factor receptor (CRFR) antagonists (α-
helical CRF, CP-154,526 and AS-30) on the maintenance and reactivation of morphine …

The possible effects on the morphine withdrawal signs of the nonspecific corticotropin‐
releasing factor (CRF) receptor antagonist α‐helical CRF, the selective CRF receptor …

The role of stress in drug addiction is well established. The negative affective states of
withdrawal most probably involve recruitment of brain stress neurocircuitry [eg, induction of …

Previous studies indicate that corticotropin‐releasing factor (CRF) contributes to the anxiety‐
like and aversive states associated with drug‐induced withdrawal. The present study …

Altered motivational processes are key features of drug dependence and withdrawal, yet
their neural mechanisms remain largely unknown. The present study shows that genetic …

BACKGROUND AND PURPOSE Recent evidence suggests that corticotropin‐releasing
factor (CRF) receptor signalling is involved in modulating the negative symptoms of opiate …

Escape from the extremely aversive opiate withdrawal symptoms powerfully motivates
compulsive drug-seeking and drug-taking behaviors. The corticotropin-releasing factor …