Background: The most important mechanism of drug resistance is related to the over-
expression of P-glycoprotein which is encoded by the MDR1 gene. The expression of MDR1 …

One important mechanism of drug resistance in acute leukemia is the overexpression of the
multi-drug resistance (MDR1) gene that encodes a 170-kDa membrane protein called P …

BACKGROUND: The expression of the multidrug resistance-1 (MDR-1) gene which encodes
p-glycoprotein, is recognized as a biological mechanism possibly contributing to treatment …

The authors established a highly sensitive, specific and quantitative method-RT-PCR for
measuring the levels of MDR1 mRNA in 91 acute leukemic samples (including 30 untreated …

Methods The expression of multidrug resistance gene (mdr1) mRNA was measured in 85
patients with acute leukemia and in 20 normal controls by using reverse transcription …

The method of reverse transcription coupled with polymerase chain reaction (RT-PCR) has
been used to detect multidrug resistance gene MDR1 expression in 73 leukemia patients …

The aim of this prospective study was to analyze the expression of messenger RNA of
genes, such as MDR1, MRP1, BCRP, and LRP, implicated in the mechanism of multidrug …

To evaluate the frequency and the prognostic value of different mechanisms of drug
resistance in acute leukemias, we investigated the expression of mdr 1 by …

Expression of the multidrug resistance gene mdr1 is reported to be an important determinant
of responsiveness to therapy and survival in some cancers. Many different methods have …

Acute myeloid leukemia (AML) has a poor long-term prognosis, with a disease-free survival
rate of only 20%. Drug resistance remains the major obstacle in this disease, although …