Alcohol metabolism is one of the biological determinants that can significantly influence
drinking behavior and the development of alcoholism and alcohol-induced organ damage …

The factors that govern blood and tissue concentrations of ethanol after its ingestion are the
rate of absorption from the gastrointestinal tract, the space of distribution in the body, and the …

The primary enzymes involved in alcohol metabolism are alcohol dehydrogenase (ADH)
and aldehyde dehydrogenase (ALDH). Both enzymes occur in several forms that are …

The occurrence of functional polymorphisms in alcohol-metabolizing enzymes makes them
favored candidate genes suitable for further molecular genetic research. A positive selection …

The pharmacokinetics of alcohol determines the time course of alcohol concentration in
blood after the ingestion of an alcoholic beverage and the degree of exposure of organs to …

Alcohol use disorders (AUDs) are complex traits, meaning that variations in many genes
contribute to the risk, as does the environment. Although the total genetic contribution to risk …

The effects of beverage alcohol (ethanol) on the body are determined largely by the rate at
which it and its main breakdown product, acetaldehyde, are metabolized after consumption …

Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are the principal
enzymes responsible for metabolism of ethanol. Both ADH and ALDH exhibit genetic …

In present day Western societies as well as in developing countries, ethanol (alcohol, ethyl
alcohol) is the most common mood and behavior altering pharmacologic agent or drug …

To evaluate the independent and interactive contributions of alcohol dehydrogenase-2
(ADH2), aldehyde dehydrogenase-2 (ALDH2) and ethanol-induced isozyme cytochrome …