Background To evaluate whether intravenous colistin in combination with other antibiotics
(IVCC) is associated with lower mortality compared with intravenous colistin monotherapy …

Objectives Colistin represents a polypeptide used for the treatment of MDR microorganisms,
although the optimal dosing strategy is under investigation. The present meta-analysis aims …

Colistin is considered a last treatment option for multi-drug and extensively resistant Gram-
negative infections. We aimed to assess the available data on the dosing strategy of colistin …

This meta-analysis aims to compare intravenous colistin monotherapy and colistin-based
combination therapy against carbapenem-resistant gram-negative bacteria (GNB) infections …

Background Optimizing colistin dosing should translate to improved patient outcomes.
Methods We used data from 2 prospective cohort studies performed between 2006 and …

Background Colistin has re-entered clinical use by necessity. We aimed to assess its
effectiveness and safety compared with newer antibiotics. Methods This was a single-centre …

It is unclear whether the effectiveness of polymyxins depends on the site of infection, the
responsible pathogen, dosage, and monotherapy vs. combination therapy. We investigated …

Background The intravenous use of polymyxins has been considered to be associated with
considerable nephrotoxicity and neurotoxicity. For this reason, the systemic administration of …

Abstract Background. The US Food and Drug Administration (FDA) and European
Medicines Agency (EMA) have approved updated dose recommendations for intravenous …

Background. There is an alarming global increase in the incidence of nosocomial infections
with multidrug-resistant Gram-negative bacteria, which are often only susceptible to colistin …