Protein engineering of lantibiotics

OP Kuipers, G Bierbaum, B Ottenwälder… - Antonie Van …, 1996 - Springer
Whereas protein engineering of enzymes and structural proteins nowadays is an
established research tool for studying structure-function relationships of polypeptides and for …

Properties and applications of lantibiotics, a class of bacteriocins produced by Gram-positive bacteria

J Nagao - Journal of Oral Biosciences, 2009 - jstage.jst.go.jp
Bacteriocins are antimicrobial peptides or proteins produced by bacteria. Lantibiotics are a
class of bacteriocin produced by gram-positive bacteria that are characterized by the …

The gene encoded antimicrobial peptides, a template for the design of novel anti-mycobacterial drugs

J Carroll, D Field, PM O'Connor, PD Cotter… - Bioengineered …, 2010 - Taylor & Francis
Nisin A is the most widely characterized lantibiotic investigated to date. It represents one of
the many antimicrobial peptides which have been the focus of much interest as potential …

[HTML][HTML] In vivo activity of Nisin A and Nisin V against Listeria monocytogenesin mice

A Campion, PG Casey, D Field, PD Cotter, C Hill… - BMC microbiology, 2013 - Springer
Background Lantibiotics are post-translationally modified antimicrobial peptides, of which
nisin A is the most extensively studied example. Bioengineering of nisin A has resulted in …

'Bac'to the future: bioengineering lantibiotics for designer purposes

EM Molloy, RP Ross, C Hill - Biochemical society transactions, 2012 - portlandpress.com
Bacteriocins are bacterially produced peptides or proteins that inhibit the growth of other
bacterial strains. They can have a broad (effective against multiple genera) or narrow …

Lantibiotics: structure, biosynthesis and mode of action

O McAuliffe, RP Ross, C Hill - FEMS microbiology reviews, 2001 - academic.oup.com
The lantibiotics are a group of ribosomally synthesised, post-translationally modified
peptides containing unusual amino acids, such as dehydrated and lanthionine residues …

Lantibiotics produced by lactic acid bacteria: structure, function and applications

D Twomey, RP Ross, M Ryan, B Meaney… - Antonie Van …, 2002 - Springer
Lantibiotics are a diverse group of heavily modified antimicrobial and/or signalling peptides
produced by a wide range of bacteria, including a variety of lactic acid bacteria. Based on …

Synergistic antimicrobial interactions of nisin A with biopolymers and solubilising agents for oral drug delivery

J Flynn, A Ryan, SP Hudson - European Journal of Pharmaceutics and …, 2022 - Elsevier
In order to develop bacteriocins, like the lantibiotic nisin A, into effective alternatives to
existing antibiotics, their biophysical and physicochemical properties must first be assessed …

Bacterial lantibiotics: strategies to improve therapeutic potential

PD Cotter, C Hill, RP Ross - Current Protein and Peptide …, 2005 - ingentaconnect.com
Lantibiotics are ribosomally-synthesised antimicrobial peptides produced by Gram-positive
bacteria that are characterised by the presence of lanthionine and/or methyllanthionine …

[HTML][HTML] Incorporation of tryptophan analogues into the lantibiotic nisin

L Zhou, J Shao, Q Li, AJ van Heel, MP de Vries… - Amino Acids, 2016 - Springer
Lantibiotics are posttranslationally modified peptides with efficient inhibitory activity against
various Gram-positive bacteria. In addition to the original modifications, incorporation of non …