Research on proteoglycans originally advanced using connective tissues such as cartilage
as a source. In the 1990s, it was found that multiple species of proteoglycans, both heparan …

Chondroitin sulfate proteoglycans (CSPGs) is one kind of proteins that covalently bind with
chondroitin sulfate. CSPGs play important roles in the growth and development of the central …

The structure and function of the nervous system is highly dependent on cellular
interactions. Indeed, the fundamental unit of brain function, the synapse, is actually a highly …

Massey et al., for example, applied chondroitinase ABC, a chondroitin sulfate-degrading
enzyme, combined with neurotrophin-3 (NT-3), one of the neurotrophic factors, to the dorsal …

Publisher Summary Increased levels of chondroitin sulfate proteoglycan (CSPG)
characterize responses to various types of tissue injury both in the periphery and in the …

The extracellular matrix is a diverse composition of glycoproteins and proteoglycans found
in all cellular systems. The extracellular matrix, abundant in the mammalian central nervous …

Publisher Summary This chapter focuses on the changes in the expression of the axon
growth-inhibitory chondroitin sulphate proteoglycans (CSPGs). CSPGs represent a varied …

Nervous tissues contain a variety of proteoglycans (1–3). In tissues, proteoglycans are
present predominantly in extracellular matrices and on cell surfaces. Proteoglycans in …

In the adult mammalian brain and spinal cord, neuronal injury results in failed neurite
regeneration, in part due to the up-regulation of chondroitin sulfate proteoglycans (CSPGs) …

The extracellular matrix (ECM) of the central nervous system (CNS) occupies a large part of
the neural tissue. It serves a variety of functions ranging from support of cell migration and …