Asymptomatic hyperuricaemia affects~ 20% of the general population in the USA, with
variable rates in other countries. Historically, asymptomatic hyperuricaemia was considered …

Epidemiological and experimental studies have shown that hyperuricaemia and gout are
intricately linked with hypertension, metabolic syndrome, chronic kidney disease and …

During the last century, there has been an increasing prevalence of hyperuricaemia noted in
many populations. While uric acid is usually discussed in the context of gout …

Hyperuricemia, ie increased serum uric acid (UA) concentration, is a common problem in
clinical practice. While there are clear guidelines concerning management of symptomatic …

Asymptomatic hyperuricemia is frequently observed in patients with kidney disease.
Although a substantial number of epidemiologic studies have suggested that an elevated …

Hyperuricemia and gout are independent risk factors associated with the development of
hypertension, metabolic syndrome, vascular damage, and renal disease. Whether these risk …

Urate is the end-product of the purine metabolism in humans. The dominant source of urate
is endogenous purines and the remainder comes through diet. Approximately two thirds of …

Uric acid is a waste product of purine catabolism. This molecule comes to clinical attention
when it nucleates to form crystals of monosodium urate (MSU) in joints or other tissues, and …

Gout and hyperuricaemia are two clinical situations associated with an elevated risk of
developing cardiovascular (heart failure, myocardial infarction, stroke) and metabolic and …

Over the past decade, significant advances have been made regarding the pathogenesis,
clinical implications, and treatment of hyperuricemia. While physicians have understood for …