Mitochondria play a central role in a plethora of processes related to the maintenance of
cellular homeostasis and genomic integrity. They contribute to preserving the optimal …

The eukaryotic cell possesses specialized pathways to turn over and degrade redundant
proteins and organelles. Each pathway is unique and responsible for degradation of …

Alzheimer's Disease (AD) is one of the most common age-related neurodegenerative
diseases in the developed world. Treatment of AD is particularly challenging as the drug …

Mutations causing genetic forms of Parkinson's disease or hereditary neuropathies have
been recently shown to affect key molecular players involved in the recycling of defective …

Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of …

In neurons, mitochondria are enriched to provide energy and calcium buffering required for
synaptic transmission. Additionally, mitochondria localize to the synapse, where they are …

Importance of the field: The socioeconomic burden of an aging population has accelerated
the urgency of novel therapeutic strategies for neurodegenerative disease. One possible …

Neurodegenerative diseases are a common late-life scourge for which disease-modifying
treatments are sorely needed. Mitochondrial perturbation is commonly observed in these …

Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …