The endosymbiosis of mitochondria and the resulting increase in energy supply thus
conferred upon the eukaryotic cell enabled the evolution of multicellular organisms and …

Alzheimer's disease (AD) is the most frequent cause of age-related neurodegeneration and
cognitive impairment, and there are currently no broadly effective therapies. The underlying …

Mitochondria are essential organelles for neuronal function and cell survival. Besides the
well-known bioenergetics, additional mitochondrial roles in calcium signaling, lipid …

Mitochondrial dysfunction remains a pivotal mechanism in manifold neurodegenerative
diseases. Mitochondrial homeostasis within the cell is an essential aspect of cell biology …

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Mitochondrial dysfunction represents a well-established player in the pathogenesis of both
monogenic and idiopathic Parkinson's disease (PD). Initially originating from the observation …

Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Background: Mitochondria are widely reported to occupy a unique role in modulating cell
viability, senescence and death. This is consistently supported by the multiple functions of …

Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Mitochondria are considered the powerhouse of the cell and disturbances in mitochondrial
functions are involved in several disorders such as neurodegeneration and mitochondrial …