Antibodies to cryptic epitopes in distant homologues underpin a mechanism of heterologous immunity between plasmodium vivax PvDBP and plasmodium falciparum …
CJ Mitran, A Mena, S Gnidehou, S Banman, E Arango… - MBio, 2019 - Am Soc Microbiol
Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to
evade host immunity. This poses a significant challenge for the host to develop broadly …
evade host immunity. This poses a significant challenge for the host to develop broadly …
Generation of a peptide vaccine candidate against falciparum placental malaria based on a discontinuous epitope
CJ Mitran, LM Higa, MF Good, SK Yanow - Vaccines, 2020 - mdpi.com
In pregnant women, Plasmodium falciparum-infected red blood cells adhere to the placenta
via the parasite protein VAR2CSA. Two vaccine candidates based on VAR2CSA are …
via the parasite protein VAR2CSA. Two vaccine candidates based on VAR2CSA are …
Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA
S Gnidehou, CJ Mitran, E Arango… - The Journal of …, 2019 - academic.oup.com
Abstract Background In pregnancy, Plasmodium falciparum parasites express the surface
antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A …
antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A …
Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strains
JYA Doritchamou, R Morrison, JP Renn… - Communications …, 2019 - nature.com
Two vaccines based on Plasmodium falciparum protein VAR2CSA are currently in clinical
evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa …
evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa …
Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes
M Avril, MM Cartwright, MJ Hathaway… - Infection and …, 2010 - Am Soc Microbiol
Pregnancy-associated malaria is a severe clinical syndrome associated with the
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant Women
M Hommel, SR Elliott, V Soma, G Kelly… - Infection and …, 2010 - Am Soc Microbiol
Pregnant women are infected by specific variants of Plasmodium falciparum that adhere and
accumulate in the placenta. Using serological and molecular approaches, we assessed the …
accumulate in the placenta. Using serological and molecular approaches, we assessed the …
Identification of an immunogenic broadly inhibitory surface epitope of the Plasmodium vivax Duffy binding protein ligand domain
MT George, JL Schloegel, FB Ntumngia, SJ Barnes… - Msphere, 2019 - Am Soc Microbiol
ABSTRACT The Plasmodium vivax Duffy binding protein region II (DBPII) is a vital ligand for
the parasite's invasion of reticulocytes, thereby making this molecule an attractive vaccine …
the parasite's invasion of reticulocytes, thereby making this molecule an attractive vaccine …
Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites
P Fernandez, NK Viebig, S Dechavanne, C Lépolard… - Malaria Journal, 2008 - Springer
Background Pregnancy-associated malaria (PAM) is a serious consequence of Plasmodium
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
Pathogenesis of Plasmodium falciparum malaria: the roles of parasite adhesion and antigenic variation
JG Beeson, GV Brown - Cellular and Molecular Life Sciences CMLS, 2002 - Springer
Malaria results in up to 2.5 million deaths annually, with young children and pregnant
women at greatest risk. The great majority of severe disease is caused by Plasmodium …
women at greatest risk. The great majority of severe disease is caused by Plasmodium …
VAR2CSA and protective immunity against pregnancy-associated Plasmodium falciparum malaria
People living in areas with stable transmission of P. falciparum parasites acquire protective
immunity to malaria over a number of years and following multiple disease episodes …
immunity to malaria over a number of years and following multiple disease episodes …