The data on fentanyl pharmacokinetics in neonates reported by Koehntop et al.(1) exhibit
considerable variability. The coefficients of variation [standard deviation/mean] x 100% of …

The pharmacokinetics of fentanyl were studied in fourteen neonates undergoing major
surgical procedures. Five patients were less than 1 day of age, seven ruere 1-4 days old …

To determine whether the clearance of fentanyl in neonates varies with age, the authors
determined the pharmacokinetics of fentanyl in 14 humans ages 1-71 days and 15 lambs …

Although fentanyl administration by continuous infusion in newborns during ventilatory
support has increased, pharmacokinetic data are lacking. Our objective was to determine …

Aims: Fentanyl is a potent opioid analgesic used within the hospital setting for the
management of acute pain within children following surgical procedures. The dosing of …

To evaluate whether there are age-related differences in the plasma concentration-vs-time
course of fentanyl, the authors administered fentanyl to seven infants (3–10 months), seven …

BACKGROUND: Fentanyl is widely used for analgesia and sedation in neonates, but
pharmacokinetic (PK) analysis in this population has been limited by the relatively large …

Fentanyl and its derivatives sufentanil, alfentanil, and remifentanil are potent opioids. A
comprehensive review of the use of fentanyl and its derivatives in the pediatric population …

Fentanyl is a synthetic opioid that is very important in anesthetic practice because of its
relatively short time to peak analgesic effect and the rapid termination of action after small …

Objective: To provide a rational basis for the dosage of fentanyl in newborn infants by
determining clearance in the first days of life. Study design: A continuous infusion of fentanyl …