Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations

SS Song, CP Sun, JJ Zhou, L Chu - International journal of biological …, 2019 - Elsevier
In our search for natural human carboxylesterase 2 (hCE 2) inhibitors from natural products,
we investigated inhibitory effects and mechanisms of flavonoids (1–16) against hCE 2. The …
被引用次数：19 相关文章 所有 6 个版本

Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2

ZM Weng, GB Ge, TY Dou, P Wang, PK Liu, XH Tian… - Bioorganic …, 2018 - Elsevier
Human carboxylesterases (hCEs) are key enzymes from the serine hydrolase superfamily.
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …
被引用次数：64 相关文章 所有 3 个版本
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[HTML][HTML] Structure-activity relationships of pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1

LW Zou, TY Dou, P Wang, W Lei, ZM Weng… - Frontiers in …, 2017 - frontiersin.org
Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed
in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic …
被引用次数：57 相关文章 所有 6 个版本

Phytochemical constituents from Uncaria rhynchophylla in human carboxylesterase 2 inhibition: kinetics and interaction mechanism merged with docking simulations

YL Wang, PP Dong, JH Liang, N Li, CP Sun, XG Tian… - Phytomedicine, 2018 - Elsevier
Abstract Background Carboxylesterases (CEs) belong to the serine hydrolase family, and
are in charge of hydrolyzing chemicals with carboxylic acid ester and amide functional …
被引用次数：32 相关文章 所有 6 个版本

Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2

LW Zou, YG Li, P Wang, K Zhou, J Hou, Q Jin… - European journal of …, 2016 - Elsevier
Abstract Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the
human intestine and various tumour tissues, plays important roles in the oral bioavailability …
被引用次数：78 相关文章 所有 4 个版本

Demethylbellidifolin isolated from Swertia bimaculate against human carboxylesterase 2: Kinetics and interaction mechanism merged with docking simulations

TT Liu, XK Huo, XG Tian, JH Liang, J Yi, XY Zhang… - Bioorganic …, 2019 - Elsevier
In this study, forty-nine kinds of traditional Chinese medicines (TCMs) were evaluated for
their inhibitory activities against human carboxylesterase 2 (HCE 2) using a human liver …
被引用次数：13 相关文章 所有 4 个版本

Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1

PF Song, YD Zhu, HY Ma, YN Wang, DD Wang… - Fitoterapia, 2019 - Elsevier
Abstract Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes,
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …
被引用次数：16 相关文章 所有 3 个版本

Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1

YQ Wang, ZM Weng, TY Dou, J Hou, DD Wang… - International journal of …, 2018 - Elsevier
Abstract Human carboxylesterase 1 (hCE1) is a key enzyme responsible for the hydrolysis of
a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors …
被引用次数：50 相关文章 所有 6 个版本
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[HTML][HTML] Novel protostane-type triterpenoids with inhibitory human carboxylesterase 2 activities

ZJ Zhang, XK Huo, XG Tian, L Feng, J Ning, XY Zhao… - RSC …, 2017 - pubs.rsc.org
The rhizomes of Alisma orientalis have been used for centuries in China and other Asian
countries as an effective herbal remedy. The phytochemical investigation of A. orientalis and …
被引用次数：28 相关文章 所有 7 个版本

Discovery of natural alkaloids as potent and selective inhibitors against human carboxylesterase 2

YS Zhao, XK Qian, XQ Guan, PF Song, YQ Song… - Bioorganic …, 2020 - Elsevier
Abstract Human Carboxylesterase 2A (hCES2A), one of the most important serine
hydrolases, plays crucial roles in the hydrolysis and the metabolic activation of a wide range …
被引用次数：14 相关文章 所有 4 个版本